{
  "abstract": "Advanced Parkinson’s disease poses numerous management challenges related to an increasingly inconsistent and unpredictable response to oral levodopa therapy, complicated by disabling motor and non-motor fluctuations and dyskinesias. Deep brain stimulation, levodopa-carbidopa intestinal gel and subcutaneous apomorphine are established non-oral treatments for advanced Parkinson’s disease but delivery of these therapies is restricted to small numbers in specialist centres. Continuous subcutaneous foslevodopa-foscarbidopa infusion (CSFFI) therapy may address this unmet need. Here, we provide experience and practical insights from delivering a CSFFI service within the UK National Health Service. We highlight advantages of CSFFI vs alternative device-aided treatment options and outline a framework for starting and maintaining treatment, including managing common side effects, illustrated by patient cases.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Duncan Street"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Lara Teare"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Andrea Lindahl"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Hannah Martin"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Bonita Bateman"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Lucy Strens"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Amrit-deep P Samra"
    }
  ],
  "title": "Foslevodopa-foscarbidopa infusion",
  "uid": "3f7f2137-8269-5c9b-9941-8100ba343099"
}