{
  "abstract": "Aims Heart failure (HF) often coexists with chronic kidney disease (CKD), impacting prognosis. This study aims to evaluate renal function trajectories and their impact on major clinical outcomes in a cohort of patients hospitalised for ‘de novo’ HF with reduced ejection fraction (HFrEF).Methods This is a prospective cohort study that included patients hospitalised for ‘de novo’ HFrEF at two university hospitals. Renal function was assessed using the CKD-Epidemiology Collaboration formula. Total mortality and the combined total mortality and HF readmissions were evaluated during follow-up.Results Of 370 patients, 306 were eligible. At discharge, 24.6% had estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m 2. Higher eGFR at discharge was associated with better outcomes. During follow-up, 79.1% showed eGFR ≥45 mL/min/1.73 m2. Patients with stable or improved eGFR had lower total mortality and HF readmission rates. Factors associated with renal function improvement or stabilisation included less prior CKD, hypertension and younger age, higher eGFR values at discharge and more use of quadruple therapy at the end of uptitration period.Conclusions In patients with ‘de novo’ HFrEF, renal function deterioration at discharge correlated with poorer outcomes. However, stabilisation or improvement during follow-up was linked to better prognosis. Routine renal function assessment is crucial in HFrEF management, guiding personalised treatment strategies to mitigate renal function decline and improve patient care.",
  "authors": [
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Oscar Otero Garcia"
    },
    {
      "affiliations": [
        "La Fe University and Polytechnic Hospital, Valencia, Spain"
      ],
      "name": "Víctor Donoso Trenado"
    },
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Pablo de la Fuente-López"
    },
    {
      "affiliations": [
        "La Fe University and Polytechnic Hospital, Valencia, Spain"
      ],
      "name": "Raquel López Vilella"
    },
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Javier Adarraga-Gómez"
    },
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Carlos Yebra Pimentel-Brea"
    },
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Guillermo Gallego-Latorre"
    },
    {
      "affiliations": [
        "University Hospital of Santiago de Compostela Servicio de Cardiología, Santiago de Compostela, Spain"
      ],
      "name": "María Inés Gómez-Otero"
    },
    {
      "affiliations": [
        "Cardiology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK",
        "Doctorate student of University of Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "Noelia Bouzas Cruz"
    },
    {
      "affiliations": [
        "Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"
      ],
      "name": "David Garcia-Vega"
    },
    {
      "affiliations": [
        "La Fe University and Polytechnic Hospital, Valencia, Spain"
      ],
      "name": "Luis Almenar Bonet"
    },
    {
      "affiliations": [
        "Cardiology Department, University Hospital of Santiago de Compostela Servicio de Cardiología, Santiago de Compostela, Spain"
      ],
      "name": "Jose Ramon Gonzalez Juanatey"
    }
  ],
  "title": "Renal function trajectories in ‘De Novo’ heart failure with reduced ejection fraction: impact on outcomes",
  "uid": "f1c45ca6-301e-5d3b-8d19-bb2455b8d968"
}