{
  "abstract": "Background The life-long exposure of the left heart chambers to systemic blood pressures may be important to changes in left atrial (LA) function with age, but long-term follow-up studies are scarce. We aimed to assess the impact of blood pressure in mid-life on LA function assessed by echocardiographic reservoir (LASr) and contractile (LASct) strain two decades later, in men and women.Methods Echocardiography was performed at ages 62–65 in 3706 participants born in 1950 of the prospective observational Akershus Cardiac Examination (ACE) 1950 Study. Data was linked with blood pressure measurements from the Age 40 Programme, a national health survey performed when the participants were 40–43 years of age. Participants were categorised into three groups representing normal blood pressure, elevated blood pressure and hypertension, based on measurements at ages 40–43. Linear regression models were used to assess associations between blood pressure and echocardiographic LA strain analysis.Results A total of 2399 participants (51.6% women) had available LA strain analysis from the ACE 1950 Study (mean age 63.9±0.6 years) and blood pressure data from the Age 40 Programme (mean age 40.1±0.3 years). At ages 62–65, mean LASr was 35.1±9.2% and LASct was 17.7±5.6%. Adjusted regression models showed a significant association between blood pressure category increase at ages 40–43 and LASct (adjusted β 1.03% (95% CI 0.37% to 1.69%), p=0.002) at ages 62–65, but not with LASr. In women, no associations were evident between blood pressure at ages 40–43 and LA strain two decades later.Conclusions Increased blood pressure in the early 40s was associated with higher LA contractile strain two decades later in men, but not in women.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway",
        "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Magnar Gangås Solberg"
    },
    {
      "affiliations": [
        "Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"
      ],
      "name": "Trygve Berge"
    },
    {
      "affiliations": [
        "Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"
      ],
      "name": "Peter Selmer Rønningen"
    },
    {
      "affiliations": [
        "Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"
      ],
      "name": "Steve Enger"
    },
    {
      "affiliations": [
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway",
        "KG Jebsen Center for Cardiac Biomarkers, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Mohammad Osman Pervez"
    },
    {
      "affiliations": [
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway"
      ],
      "name": "Eivind Bjørkan Orstad"
    },
    {
      "affiliations": [
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway",
        "KG Jebsen Center for Cardiac Biomarkers, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Brede Kvisvik"
    },
    {
      "affiliations": [
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway",
        "KG Jebsen Center for Cardiac Biomarkers, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Erika Nerdrum Aagaard"
    },
    {
      "affiliations": [
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway",
        "KG Jebsen Center for Cardiac Biomarkers, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Magnus Nakrem Lyngbakken"
    },
    {
      "affiliations": [
        "Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway"
      ],
      "name": "Inger Ariansen"
    },
    {
      "affiliations": [
        "KG Jebsen Center for Cardiac Biomarkers, Faculty of Medicine, University of Oslo, Oslo, Norway",
        "Akershus Clinical Research Center (ACR), Division of Research and Innovation, Akershus University Hospital, Lørenskog, Norway"
      ],
      "name": "Helge Rosjo"
    },
    {
      "affiliations": [
        "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway",
        "Department of Cardiology, Akershus University Hospital, Lørenskog, Norway"
      ],
      "name": "Kjetil Steine"
    },
    {
      "affiliations": [
        "Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway",
        "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"
      ],
      "name": "Arnljot Tveit"
    }
  ],
  "title": "Long-term impact of blood pressure in women and men in their early 40s on left atrial strain: data from the Akershus Cardiac Examination (ACE) 1950 Study",
  "uid": "1cd22c68-ac63-5177-a807-b61689942ab5"
}