{
  "abstract": "Objective To clarify whether atherogenic index of plasma (AIP), a comprehensive indicator reflecting both the protective and atherogenic effects of lipoproteins on cardiometabolic health, is associated with increased risk of aortic disease.Design Large-scale, population-based, observational, prospective cohort study.Data sources Health dataset from UK Biobank.Participants A total of 17 530 participants, aged 40–70 years, were enrolled and completed the initial assessment visit before 2010. Participants with a history of aortic dissection (AD) or aortic aneurysm (AA), baseline connective tissue disease, missing triglyceride and high-density lipoprotein cholesterol values, fasting time less than 8 hours or those lost to follow-up were excluded.Main outcome measures Aortic disease, a composite outcome comprising AD and AA.Results During a median follow-up period of 15.1 years, 164 aortic disease cases, including 14 AD and 155 AA cases, were documented. A linear trend between AIP and the risk of incident aortic disease was confirmed (p for non-linear=0.134). The multivariable-adjusted incident risk of aortic disease gradually increased with elevated AIP tertiles (adjusted HR (aHR) 1.0 (reference) in tertile 1, aHR 1.48 (95% CI 0.91 to 2.41) in tertile 2, aHR 2.04 (95% CI 1.26 to 3.29) in tertile 3), following an adjustment for age, sex, smoking status, drinking status, body mass index, hypertension, low-density lipoprotein cholesterol and glycated haemoglobin. Specifically, participants in the highest AIP tertile had the highest incident risk of AA, with an aHR of 2.47 (95% CI 1.47 to 4.16).Conclusions AIP is significantly associated with a higher risk of incident aortic disease, indicating that AIP is an effective risk assessment method for aortic disease, especially for AA.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Human Phenome Institute of Shantou University Medical College, Guangdong Engineering Research Centre of Human Phenome, Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong 515063, China",
        "Glycome Research Institute, Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Clinical Medical Research Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Molecular Cardiology Laboratory, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Cuihong Tian"
    },
    {
      "affiliations": [
        "Joint Cardiac Surgery Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Xiao Wang"
    },
    {
      "affiliations": [
        "Joint Cardiac Surgery Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Liang Tao"
    },
    {
      "affiliations": [
        "Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Wanyi Wei"
    },
    {
      "affiliations": [
        "Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Xuan Zhang"
    },
    {
      "affiliations": [
        "Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Haoxian Tang"
    },
    {
      "affiliations": [
        "Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Human Phenome Institute of Shantou University Medical College, Guangdong Engineering Research Centre of Human Phenome, Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong 515063, China"
      ],
      "name": "Yequn Chen"
    },
    {
      "affiliations": [
        "Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China",
        "Human Phenome Institute of Shantou University Medical College, Guangdong Engineering Research Centre of Human Phenome, Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong 515063, China",
        "Clinical Medical Research Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China"
      ],
      "name": "Xuerui Tan"
    }
  ],
  "title": "Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis",
  "uid": "ab0cb276-2ba0-51a2-8356-ac3641cefab9"
}