{
  "abstract": "Background Stroke volume is an established echocardiographic marker but has not been widely studied in patients with ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate stroke volume in a cohort of uncomplicated anterior STEMI and to assess its prognostic role in those with severe left ventricle (LV) systolic dysfunction.Methods and results This is a single-centre retrospective analysis of consecutive patients presenting with anterior STEMI who underwent uncomplicated primary percutaneous coronary intervention. Stroke volume was measured using echocardiography within in-hospital admission. The primary endpoint was cardiovascular mortality. Of 3592 patients with STEMI, 616 were included. The mean age was 65±14 years (76% males). The average left ventricular ejection fraction (LVEF) and stroke volume were 39±11% and 62±18 mL, respectively. There was a modest relationship between stroke volume and LVEF (r=0.33, p<0.001), which was not maintained in patients with severe LV dysfunction (r=0.11, p=0.19). On multivariate analysis, stroke volume was associated with cardiovascular death at 12 months (HR 0.92, 95% CI 0.86 to 0.98, p=0.015) in patients with severe LV systolic dysfunction. Receiver operating characteristic analysis demonstrated an area under the curve of 0.80 (95% CI 0.70 to 0.91, p<0.001) in this group with negative predictive value of 99% for cardiovascular mortality.Conclusions Stroke volume is a readily and useful echocardiographic marker to assess prognosis in patients with anterior STEMI and severe LV systolic dysfunction. It identifies with a high degree of certainty those patients who are likely to survive despite their severe LV systolic dysfunction.",
  "authors": [
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Muntaser Omari"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Natasha James"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Andrew Brown"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Kadhim Kadhim"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Bilal Bawamia"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Adam McDiarmid"
    },
    {
      "affiliations": [
        "Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Mohammad Alkhalil"
    }
  ],
  "title": "Role of stroke volume in patients presenting with uncomplicated anterior STEMI",
  "uid": "ee168a14-d8cb-524e-aece-bacb7192c695"
}