{
  "abstract": "Background Long-term outcome of contemporary myocardial perfusion scintigraphy (MPS) has not been assessed systematically.Objective To evaluate the association between results of MPS and long-term outcomes for patients with suspected coronary artery disease (CAD).Methods Electronic databases were searched for Randomised controlled trials evaluating long-term outcome (≥12 months) of MPS in patients with suspected of CAD since year 2000. A meta-analysis adopting the random effects model was used to derive pooled estimates. The primary outcome was the composite of all-cause or cardiovascular mortality and non-fatal myocardial infarction as defined in individual trials, termed as major adverse cardiovascular event (MACE). Secondary outcome was all-cause or cardiovascular mortality. Positive MPS result was defined as reversible perfusion defect in any coronary artery territory.Results Four trials fulfilled the search criteria. A total of 1764 patient had MPS with a median follow-up of 35.7 months (range 17–57). The mean age was 59 years and 50% were male. Fifty-three per cent had hypertension, 43% had dyslipidaemia, 15% were current smokers and 61% had diabetes mellitus. The overall annual event rate was 1.42% for the composite MACE and 0.22% for all-cause or cardiovascular mortality. Compared with negative MPS results, positive MPS was associated with an increased risk of the composite MACE and all-cause or cardiovascular mortality with an annual event rate of 2.16% versus 0.66%, OR 2.71 (1.38, 5.32) and 0.34% versus 0.10%, OR 3.41 (1.44, 8.11), respectively.Conclusion In this meta-analysis, reversible perfusion defect on MPS was associated with higher risk of composite MACE, and that of all-cause or cardiovascular mortality.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiovascular Sciences, University of Leicester, Leicester, UK",
        "Translational Cardiovascular Research Group, Department of Cardiology, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK"
      ],
      "name": "Ugochukwu Ihekwaba"
    },
    {
      "affiliations": [
        "Translational Cardiovascular Research Group, Department of Cardiology, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK"
      ],
      "name": "Nicholas Johnson"
    },
    {
      "affiliations": [
        "Translational Cardiovascular Research Group, Department of Cardiology, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK"
      ],
      "name": "Ji Soo Choi"
    },
    {
      "affiliations": [
        "Department of Medicine, Karolinska Institute, Stockholm, Sweden"
      ],
      "name": "Gianluigi Savarese"
    },
    {
      "affiliations": [
        "Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Nicola Orsini"
    },
    {
      "affiliations": [
        "Glenfield Hospital, Leicester, England, UK"
      ],
      "name": "Jeffrey Khoo"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"
      ],
      "name": "Iain Squire"
    },
    {
      "affiliations": [
        "Translational Cardiovascular Research Group, Department of Cardiology, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK",
        "Faculty of Medicine and Health Sciences, University of Buckingham, Buckingham, UK"
      ],
      "name": "Attila Kardos"
    }
  ],
  "title": "Long-term prognostic value of myocardial perfusion scintigraphy in patients with suspected coronary artery disease: systematic review and meta-analysis",
  "uid": "0e0e9838-bef0-5a0c-80e1-9c94795f8302"
}