{
  "abstract": "Objective To assess the association between parental occupational pesticide exposures at birth and adult testicular germ cell tumour (TGCT) by histological subtype and the agreement between two pesticide job-exposure matrices (JEM).Methods TGCT cases (n=454) and matched controls (n=670) aged 18–45 years were recruited from 20 French university hospitals into the TESTIS national case-control study. Paternal and maternal jobs at birth were obtained from interviews of participants and their mothers/relatives and coded into official nomenclatures (International Standard Classification of Occupations, French nomenclature of activity-1999). Two complementary JEMs, ALOHA+ and FRIJEM, assessed occupational exposure to all pesticides, herbicides, insecticides, fungicides with ALOHA+ for each parent by linking job titles to JEM-derived probability and intensity estimates (no/low/high). Cohen’s Kappa coefficient (κ) assessed their agreement. ORs and 95% CIs comparing exposure and levels of exposure with no exposure were estimated using conditional logistic regression adjusted for literature-based covariates statistically associated with TGCT and stratified by histological subtypes.Results Agreement between ALOHA+and FRIJEM was moderate to substantial (κ 0.52–0.80). A statistically non-significant higher TGCT risk was observed for high paternal occupational pesticide exposure with ALOHA+ (OR 1.95, CI 0.98 to 3.84) and FRIJEM (OR 1.70, CI 0.88 to 3.28). With ALOHA+, statistically significant positive associations were seen for high paternal occupational exposure to herbicides (overall: OR 4.23, CI 1.75 to 10.22; seminomas: OR 4.78, CI 1.79 to 12.77; non-seminomas: OR 3.53, CI 1.21 to 10.3) and fungicides (overall: OR 2.09, CI 1.05 to 4.18; seminomas: OR 2.31, CI 1.02 to 5.23). No statistically significant associations were observed for other levels of paternal exposure or pesticide groups nor for maternal exposure.Conclusion Only high paternal occupational exposure to pesticides at birth, especially herbicides and fungicides, was positively associated with TGCT.",
  "authors": [
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France",
        "Occupational Health Department, AMEBAT Service de Prevention et de Sante au Travail du Batiment et des Travaux Publics, Nantes, France"
      ],
      "name": "Adèle Paul"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, IARC, Lyon, France"
      ],
      "name": "Aurélie Danjou"
    },
    {
      "affiliations": [
        "Département Prévention, Cancer et Environnement, Centre Léon Bérard, Lyon, France",
        "UMR1296 Radiation: Defense, Health, Environment, INSERM, Lyon, France"
      ],
      "name": "Astrid Coste"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands"
      ],
      "name": "Hans Kromhout"
    },
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France"
      ],
      "name": "Marie Lefevre"
    },
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France",
        "Direction Santé Travail, Santé publique France, Saint-Maurice, France"
      ],
      "name": "Johan Spinosi"
    },
    {
      "affiliations": [
        "Département Prévention, Cancer et Environnement, Centre Léon Bérard, Lyon, France"
      ],
      "name": "Brigitte Dananché"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, IARC, Lyon, France"
      ],
      "name": "Ann Olsson"
    },
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France",
        "Centre de Ressources en Pathologies Professionnelles et Environnementales, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Céline Lamouroux"
    },
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France"
      ],
      "name": "Margot Guth"
    },
    {
      "affiliations": [
        "Institut de recherche en santé, environnement et travail, UMR S 1085, Université de Rennes, Rennes, France"
      ],
      "name": "Rémi Béranger"
    },
    {
      "affiliations": [
        "Département Prévention, Cancer et Environnement, Centre Léon Bérard, Lyon, France"
      ],
      "name": "Olivia Pérol"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Centre Léon Bérard, Lyon, France"
      ],
      "name": "Helen Boyle"
    },
    {
      "affiliations": [
        "Maternité, CHRU de Nancy, Nancy, France"
      ],
      "name": "Christel Hersant"
    },
    {
      "affiliations": [
        "CECOS, CHRU Montpellier Pôle Mère et enfant, Montpellier, France"
      ],
      "name": "Vanessa Loup-Cabaniols"
    },
    {
      "affiliations": [
        "CECOS, CHU de Rennes, Rennes, France"
      ],
      "name": "Segolene Veau"
    },
    {
      "affiliations": [
        "Department of Reproductive Biology, AP-HM, Marseille, France"
      ],
      "name": "Jeanne Perrin"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, IARC, Lyon, France"
      ],
      "name": "Joachim Schüz"
    },
    {
      "affiliations": [
        "UMRESTTE, Université Claude Bernard Lyon 1, Villeurbanne, France",
        "Centre de Ressources en Pathologies Professionnelles et Environnementales, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Barbara Charbotel"
    },
    {
      "affiliations": [
        "Département Prévention, Cancer et Environnement, Centre Léon Bérard, Lyon, France",
        "UMR1296 Radiation: Defense, Health, Environment, INSERM, Lyon, France"
      ],
      "name": "Béatrice Fervers"
    },
    {
      "affiliations": [],
      "name": "TESTIS study group"
    }
  ],
  "title": "Parental occupational exposure to pesticides at birth and risk of adult testicular germ cell tumours in offspring: a French nationwide case-control study",
  "uid": "6c2ab5b8-6c07-54c3-8d1b-415dbec45afd"
}