{
  "abstract": "Objectives Using a case–control design, we examined the association between occupational asbestos exposure and risk of peritoneal mesothelioma in the general population in Italy.Methods From the National Mesothelioma Registry, we selected cases (2000–2021) with life-time occupational history. Controls were 3045 from three case–control studies (region-sex-age-matched, performed in six regions), one in 2002–2004 (2116 population controls) and two in 2012–2016 (718 population and 211 hospital controls). For all subjects, exposure assignment was based on a quantitative job-exposure matrix (SYN-JEM). Qualitative expert-based evaluation was available for all cases, but only in 2012–2016 for 929 controls. We estimated ORs and 90% CIs using logistic regression models adjusted for residence, gender, period and age.Results In complete analyses (1591 cases, all years/regions), the OR for ever exposure was 3.66 (CI 3.21 to 4.18, 45.4% cases and 27.8% controls exposed). Among the exposed, median cumulative exposure (fibres/mL-years) was 1.4 (max 20.0) in cases and 1.1 (max 10.9) in controls. The OR was 1.55 (1.48 to 1.62) per log 10-transformed cumulative exposure. In analyses restricted to 290 cases (same years/regions of controls), ORs were 3.35 (2.57 to 4.37, 43.8% cases exposed) for ever exposure and 1.52 (1.39 to 1.65) for cumulative exposure. ORs for ever asbestos exposure using expert-based evaluation were particularly high, 4.32 (3.50 to 5.34, 53.9% cases and 26.4% controls exposed) in complete analyses (778 cases) and 6.35 (4.58 to 8.81, 57.1% cases exposed) in restricted analyses (245 cases), but are known to be more prone to bias.Conclusions Peritoneal mesothelioma showed clear associations with asbestos exposure using different exposure assessment methods.",
  "authors": [
    {
      "affiliations": [
        "Occupational Health Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy"
      ],
      "name": "Dario Consonni"
    },
    {
      "affiliations": [
        "COR Piemonte, Cancer Epidemiology Unit, University of Turin, Turin, Italy"
      ],
      "name": "Enrica Migliore"
    },
    {
      "affiliations": [
        "COR Piemonte, Cancer Epidemiology Unit, University of Turin, Turin, Italy"
      ],
      "name": "Manuela Gangemi"
    },
    {
      "affiliations": [
        "COR Puglia, Section of Occupational Medicine “B. Ramazzini”, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy"
      ],
      "name": "Domenica Cavone"
    },
    {
      "affiliations": [
        "COR Puglia, Section of Occupational Medicine “B. Ramazzini”, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy"
      ],
      "name": "Luigi Vimercati"
    },
    {
      "affiliations": [
        "COR Toscana, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy"
      ],
      "name": "Sara Piro"
    },
    {
      "affiliations": [
        "COR Toscana, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy"
      ],
      "name": "Lucia Giovannetti"
    },
    {
      "affiliations": [
        "COR Veneto, Azienda Zero, Padua, Italy"
      ],
      "name": "Valentina Zabeo"
    },
    {
      "affiliations": [
        "COR Veneto, Azienda Zero, Padua, Italy"
      ],
      "name": "Vera Comiati"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"
      ],
      "name": "Stefania Curti"
    },
    {
      "affiliations": [
        "Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy"
      ],
      "name": "Stefano Mattioli"
    },
    {
      "affiliations": [
        "Division of Cancer Epidemiology and Genetics, National Cancer Institute Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA"
      ],
      "name": "Maria Teresa Landi"
    },
    {
      "affiliations": [
        "COR Valle d’Aosta, Local Health Authority of Valle d’Aosta, Aosta, Italy"
      ],
      "name": "Carmela Gioscia"
    },
    {
      "affiliations": [
        "COR Province of Trento, Provincial Unit of Health, Hygiene and Occupational Medicine, Trento, Italy"
      ],
      "name": "Silvia Eccher"
    },
    {
      "affiliations": [
        "COR Province of Bolzano, Alto Adige Health Local Unit, Bolzano, Italy"
      ],
      "name": "Stefano Murano"
    },
    {
      "affiliations": [
        "COR Friuli-Venezia Giulia, University of Trieste - Trieste General Hospitals, Clinical Unit of Occupational Medicine, Trieste, Italy"
      ],
      "name": "Flavia D’Agostin"
    },
    {
      "affiliations": [
        "Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, Genoa, Italy",
        "UO Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy"
      ],
      "name": "Carlo Genova"
    },
    {
      "affiliations": [
        "COR Emilia-Romagna, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy"
      ],
      "name": "Riccardo Perduri"
    },
    {
      "affiliations": [
        "COR Marche, University of Camerino, School of Medicinal and Health Products Sciences, Camerino, Italy"
      ],
      "name": "Iolanda Grappasonni"
    },
    {
      "affiliations": [
        "COR Umbria, Servizio Prevenzione, Sanità Veterinaria e Sicurezza Alimentare - Regione Umbria, Perugia, Italy"
      ],
      "name": "Fabrizio Stracci"
    },
    {
      "affiliations": [
        "COR Lazio, Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy"
      ],
      "name": "Ilaria Cozzi"
    },
    {
      "affiliations": [
        "COR Abruzzo, Abruzzo Regional Health Agency (ASR), Pescara, Italy"
      ],
      "name": "Tommaso Staniscia"
    },
    {
      "affiliations": [
        "COR Molise, Regione Molise Cancer Registry, Campobasso, Italy"
      ],
      "name": "Franco Calista"
    },
    {
      "affiliations": [
        "COR Campania, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy"
      ],
      "name": "Italo Francesco Angelillo"
    },
    {
      "affiliations": [
        "COR Basilicata, IRCCS CROB, Rionero in Vulture, Italy"
      ],
      "name": "Rocco Galasso"
    },
    {
      "affiliations": [
        "COR Calabria, Public Health Unit, Crotone, Italy"
      ],
      "name": "Federico Tallarigo"
    },
    {
      "affiliations": [
        "COR Sicilia, Cancer Registry ASP Ragusa and Sicily Regional Epidemiological Observatory, Ragusa, Italy"
      ],
      "name": "Giuseppe Cascone"
    },
    {
      "affiliations": [
        "COR Sardegna, Regional Epidemiological Center, Cagliari, Italy"
      ],
      "name": "Massimo Melis"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Susan Peters"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Hans Kromhout"
    },
    {
      "affiliations": [
        "Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Rome, Italy"
      ],
      "name": "Alessandra Binazzi"
    },
    {
      "affiliations": [
        "Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Rome, Italy"
      ],
      "name": "Alessandro Marinaccio"
    },
    {
      "affiliations": [
        "Occupational Health Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy"
      ],
      "name": "Carolina Mensi"
    },
    {
      "affiliations": [],
      "name": "ReNaM Working Group"
    }
  ],
  "title": "Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Italy, 2000–2021",
  "uid": "74c2f0da-4288-5ee8-884a-56cde1203188"
}