{
  "abstract": "Objectives There is a lack of knowledge about whether occupational exposures increase the risk of emphysema, especially in never-smokers. Our objective was to determine if occupational exposures are associated with emphysema and impaired diffusing capacity.Methods In the Swedish CArdioPulmonary bioImage Study (SCAPIS), persons from the general population aged 50–64 answered a questionnaire and underwent CT of the lung as well as assessment of the diffusing capacity of their lungs for carbon monoxide (DL CO), presented as DLCO<lower limit of normal (LLN). Emphysema was defined as emphysema in any part of the lungs. Occupational exposures were assessed by a job exposure matrix based on longest held job. ORs with 95% CIs were calculated using logistic multivariable models.Results In this cross-sectional study (27 370 persons including 13 981 never-smokers), occupational exposure to inorganic dust was associated with emphysema (OR 1.25, 95% CI 1.07 to 1.47), also among never-smokers, (OR 1.46, 95% CI 1.00 to 2.11). There were associations with DL CO<LLN for occupational exposure to inorganic dust and vapour and gases. With all exposures in the same model, inorganic dust was associated with emphysema (OR 1.30, 95% CI 1.08 to 1.57), and vapour and gases were associated with DLCO<LLN (OR 1.17, 95% CI 1.00 to 1.38). In those with emphysema and impaired DLCO, there was an association with inorganic dust (OR 1.65, 95% CI 1.20 to 2.28), also among never-smokers (OR 3.79, 95% CI 1.35 to 10.63).Conclusions Occupational exposures to inorganic dust are associated with emphysema. The association is stronger in those with the combination of emphysema and impaired DL CO indicating serious exposure effects in the alveoli.",
  "authors": [
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Mathias Holm"
    },
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Linus Schioler"
    },
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Anna Dahlman-Hoglund"
    },
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Håkan Tinnerberg"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Martin Andersson"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Annelie Behndig"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Anders Blomberg"
    },
    {
      "affiliations": [
        "Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Kerstin Cederlund"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Jonas Eriksson Ström"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Christer Janson"
    },
    {
      "affiliations": [
        "Department of Radiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden",
        "Department of Radiology, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Åse Johnsson"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Eva Lindberg"
    },
    {
      "affiliations": [
        "Division for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden",
        "Karolinska Severe COPD Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Anders Lindén"
    },
    {
      "affiliations": [
        "Occupational and Environmental Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden"
      ],
      "name": "Stefan Ljunggren"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Andrei Malinovschi"
    },
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Anna-Carin Olin"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden",
        "Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"
      ],
      "name": "Ida Pesonen"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden",
        "Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"
      ],
      "name": "Magnus Sköld"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Magnus Svartengren"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Skånes universitetssjukhus Malmö, Lund University, Malmö, Sweden"
      ],
      "name": "Hanan Tanash"
    },
    {
      "affiliations": [
        "Department of Translational Medicine, Lund University, Malmö, Sweden"
      ],
      "name": "Per Wollmer"
    },
    {
      "affiliations": [
        "Occupational and Environmental Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden"
      ],
      "name": "Xi-Ming Yuan"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Suneela Zaigham"
    },
    {
      "affiliations": [
        "Department of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Kjell Torén"
    }
  ],
  "title": "Occupational exposures to inorganic dust are associated with emphysema: the SCAPIS cohort",
  "uid": "1582d32b-be65-5d07-bf09-92946552ec34"
}