{
  "abstract": "Objective To estimate the prevalence of chronic kidney disease (CKD) and to explore associations with occupational exposures among workers in an agricultural area of Chile.Material and Methods A cross-sectional study was conducted within the MAUCO cohort in Molina, including 1,006 participants aged 41–81 years (566 women [56.3%], 440 men [43.7%]). Occupational factors included current employment, agricultural work and pesticide exposure. Data were collected using the DEGREE protocol. Risk factors for CKD were characterized, and biological samples were collected. Estimated glomerular filtration rate (eGFR, in mL/min/1.7m2) was calculated using the CKD-EPI 2021 equation and categorized according to KDIGO guidelines: <60 (moderate to severe decrease, CKD definition), 60–90 (mild decrease), and >90 (normal). Adjusted logistic regression models examined factors associated with eGFR <90.Results Mean age was 55.1 ± 7.5 years; 35.6% had <8 years of education, 44.9% had obesity, 22.9% diabetes, and 34.7% hypertension. Most participants worked in agriculture (57.1%), half of them in elementary occupations. Median eGFR was 88.7 mL/min/1.73 m² in women and 88.9 in men. eGFR was >90 in 56.6%, 60–90 in 50.9%, and <60 in 2.6% (CKD), with no differences by sex. Lower eGFR was significantly associated with older age, hypertension, higher creatinine, uric acid, BUN, and unemployment (p<0.05). Agricultural and pesticide exposures were more frequent in the CKD group. In regression analysis, hypertension and diuretic use were associated with eGFR <90, while female sex and being employed were associated with lower odds.Conclusion This is the first study in Chile to investigate traditional and non-traditional risk factors associated with CKD. In this sample of workers, CKD prevalence was lower than the one reported for Chilean adult population in the last national survey (2.6% vs 3.2%). Impaired kidney function was linked to known risk factors and social vulnerability. Although not significant, the trend with agricultural exposure warrants further investigation into occupational risks in rural populations.",
  "authors": [
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Sandra Cortes"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Jenny Ruedlinger"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "María José Ojeda"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Cinthya Leiva"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Margarita Valenzuela"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Camilo Sotomayor"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Roberto Jalil"
    },
    {
      "affiliations": [
        "Advanced Center for Chronic Diseases, ACCDS, Santiago, Chile. Centro de Desarrollo Urbano Sustentable, CEDEUS. School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Radiology Department, Clinical Hospital University of Chile, University of Chile, Santiago, Chile. Laboratory of Medical Informatics and Telemedicine, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Nephrology, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute of Agri-food, Animal and Environmental Sciences (ICA3), Universidad de O’Higgins, San Fernando, Chile"
      ],
      "name": "Claudia Foerster"
    }
  ],
  "title": "8287562 Chronic kidney disease and occupational risk factors in agricultural workers from the Maule cohort",
  "uid": "be93a44c-2a01-5aab-b70f-fdc61da0278b"
}