{
  "abstract": "Objective In the Mount Sinai WTC General Responders’ Cohort on longitudinal health surveillance, about a third of participants who met the spirometric definition of chronic obstructive pulmonary disease (COPDspiro) have never smoked tobacco products, and we have observed less radiological emphysema. We examined the hypothesis that smoking-related COPDspiro is associated with accelerated longitudinal FEV1 decline.Methods All study subjects participated were diagnosed with COPDspiro based on post-bronchodilator FEV1/FVC<0.7. We examined differences between participants with ever vs. never smoking on longitudinal lung function trajectory based on our previous publication[PMC7605357] and defined those with an average decrease in FEV1 larger than 62.5ml/year as an accelerated decliner. We additionally compared the effect of bronchodilator response using and a five-category bronchodilator response grading strategy[PMC6956832]. We used multivariable logistic regressions to examine the odds of an accelerated FEV1 decline trajectory between ever- vs never smoking COPDspiro groups.Results Among the 504 subjects with COPDspiro, 181 (35.9%) never smoked. Compared with the ever smokers, nonsmokers were younger and more often of Latino/any race ethnicity. While the smokers had higher prevalence of high blood neutrophil count (>6000/mcl), the non-smokers had higher prevalence of self-reported asthma and evidence of bronchodilator responsiveness (BDR), and a higher proportion of subjects with marked BDR category (ΔFEV1>0.26 L or 26%). Smokers had 1.56 times higher odds (95%CI 1.01-2.42) of having dyspnea, and 1.74 times higher odds (95%CI 1.05-2.89) of having an accelerated FEV1 decline compared to non-smokers.Conclusion Among WTC responders, COPDspiro in smokers was associated with an accelerated FEV1 decline and shortness of breath compared to never smokers, while never smokers with COPD tended to have higher percentage of asthma diagnosis and a positive BDR.Funding grant U01 OH011697 from CDC/NIOSH. The WTC GRC Data Center provided the data utilized for this study (CDC/NIOSH contract 75D30122C15187). The views expressed in this work are not necessarily those of the CDC/NIOSH.",
  "authors": [
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "Zitong Zhang"
    },
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "Moshe Shapiro"
    },
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "Jonathan Weber"
    },
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "John T Doucette"
    },
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "Juan C Celedón"
    },
    {
      "affiliations": [
        "Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai. University of Pittsburgh School of Medicine"
      ],
      "name": "Rafael E de la Hoz"
    }
  ],
  "title": "8265963 Smokers with COPD had higher risk of having an accelerated lung function decline compared to non-smokers with COPD in a WTC Cohort on surveillance",
  "uid": "68918759-2329-5590-839e-5792b4812ac5"
}