{
  "abstract": "Objective Occupational contact dermatitis arises from workplace exposure to irritants or allergens, causing irritant (ICD) or allergic contact dermatitis (ACD). Individual susceptibility, influenced by personal and lifestyle factors, may affect the risk of ICD and ACD. This study aims to identify these susceptibility factors and their impact on the association between work-related exposures and contact dermatitis (CD).Methods A scoping review following PRISMA-ScR guidelines was conducted using Medline, Embase, and CINAHL. Included study designs were cohort and case-control studies for all types of CD, and cross-sectional studies for ACD. Forest plots were used to summarize the influence of non-work-related susceptibility factors on the association between work-related exposures and CD.Results Twenty-one studies, primarily cross-sectional (n=18), investigated how 44 different individual susceptibility factors influenced the associations between 53 occupational exposures (from six exposure categories) and CD. The non-work-related susceptibility factors were categorized into five categories: demographic (i.e., sex), socioeconomic (i.e., income), personal/family atopic diseases (i.e., atopic dermatitis), lifestyle (i.e., smoking), and exposure outside work (e.g., wet work). Fifteen studies adjusted for concurrent work-related factors. Most studies adjusted for multiple non-work and work-related factors leading to either an increasing or decreasing association between work-related exposure and CD.Conclusion While susceptibility factors are often adjusted for, their impact on the association between work-related exposures and CD remains inconclusive, with some factors mitigating or amplifying the risk. The majority of studies account for various work- and non-work-related susceptibility factors, complicating the isolation of their individual contributions. Our review highlights the need for more research on individual susceptibility factors and their effects, harmonizing adjustment factors, and achieving consensus on differentiating ICD and ACD for effective prevention strategies.",
  "authors": [
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Renate Juscikowski"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Pieter Coenen"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Sanja Kezic"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Damien M McElvenny"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Faridi van Etten-Jamaludin"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Henk F van der Molen"
    },
    {
      "affiliations": [
        "Amsterdam UMC Public and occupational health, Amsterdam Public Health Research Institute. Netherlands Center for Occupational Diseases. Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"
      ],
      "name": "Jan L Hoving"
    }
  ],
  "title": "8264637 The role of susceptibility in the association between exposures and occupational contact dermatitis: a scoping review",
  "uid": "66ac6852-1675-514a-8025-ca28687a86a1"
}