{
  "abstract": "Objective Investigate cancer mortality in workers of the world’s largest chrysotile mine and its enrichment factories in Asbest, Sverdlovsk region of the Russian Federation.Material and Methods The Asbest chrysotile cohort study includes 30 445 workers, whereof 32% are women, employed for at least 1 year between 1975 and 2010 and followed up until the end of 2015. Individual cumulative exposure to dust (and modelled conversion to asbestos fibres) was estimated based on workers’ occupational history linked to dust measurements systematically collected from the 1950s to 2010. Relative risks (RRs) by exposure were estimated as mortality rate ratios in Poisson regression models within the cohort, and standardized mortality ratios (SMRs) were calculated for selected cancer sites compared to the population of Sverdlovsk region for the years 1980-2015.Results An exposure-response between cumulative dust and lung cancer mortality in men was observed with a RR 1.40, 95%-confidence interval (CI) 1.03-1.90 in the ≥150 mg/m3-years category and a p-value for trend of 0.02, while in women no clear association was seen but a modest increase in the highest category of exposure to fibres. Mesothelioma mortality was increased (RR 7.64, CI 1.18 to 49.5) in the highest exposure category to fibres (≥ 80 fibres/cm3-years). Comparing the cohort vs. Sverdlovsk region for lung cancer showed SMR 1.20, CI 1.10-1.30 in men and 1.35, CI 0.97-1.83 in women. No or no consistent associations were seen for stomach, colorectal, laryngeal, or ovarian cancer.Conclusions This is the first international study to examine cancer mortality in the Russian chrysotile industry. We observed increased risks of mesothelioma and of lung cancer in men. Our comparison with the mortality of the region confirms the observed exposure-depended excess in lung cancer, especially in men.",
  "authors": [
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO). Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Ann Olsson"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO). Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Joachim Schüz"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO). Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Evgeny Kovalevskiy"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO). Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Hans Kromhout"
    },
    {
      "affiliations": [
        "Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO). Federal State Budgetary Scientific Institution, Izmerov Research Institute of Occupational Health, Moscow, Russian Federation. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Igor Bukhtiyarov"
    }
  ],
  "title": "8252003 Cancer mortality in chrysotile miners and millers in asbest in the Russian federation",
  "uid": "6577e569-c36f-51b1-aa5e-84e639b3ad0b"
}