{
  "abstract": "Objective Non-standard work schedules are becoming increasingly prevalent, with one in five workers participating in night shifts. Whether working night shifts is associated with cardiovascular-kidney-metabolic (CKM) outcomes, and whether chronotype or sleep duration modify this association, remains unclear.Material and Methods We utilized data from 96,365 UK Biobank participants (57% female, mean age 62 years), with information on employment history and tracked incidence of CKM (including cardiovascular diseases, chronic kidney diseases and/or type 2 diabetes) through 2022. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CIs), adjusting for a range of potential confounding factors.Results Based on 5,967 incident CKM cases, participants with more than 20 years of night shift work history had a significantly higher rate of CKM (HR=1.32 [95% CI, 1.20-1.45]) compared to day workers, after adjusting for sex, age, ethnicity, and socioeconomic factors. Elevated rates were also observed among those working 8 or more night shifts per month (HR=1.32 [95% CI, 1.21-1.43]) and those with over 1,200 lifetime night shifts (HR=1.36 [95% CI, 1.25-1.48]) as compared to day workers; all Ptrend<0.001. The association between night shift work and CKM risk was significantly modified by sleep duration, with higher rates among short sleepers (<7 hours/night;Pinteraction= 0.009, 0.031, and 0.017 for night shift work duration, intensity, and cumulative number of nights worked, respectively). However, chronotype did not significantly modify this association.Conclusion Our findings reveal a dose-response relationship between night shift work and CKM disease, which is further amplified by short sleep duration. Future studies should consider using CKM conditions as a composite outcome and investigate further how various sleep characteristics may modify the impact of night shift work.",
  "authors": [
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Dat Thien Tran"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Susanne Strohmaier"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Magdalena Żebrowska"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Tianyi Huang"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Kyriaki Papantoniou"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Susan Redline"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Richa Saxena"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Martin K Rutter"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. Centre for Biological Timing, Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, UK. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"
      ],
      "name": "Eva Schernhammer"
    }
  ],
  "title": "8287405 Risk of cardiovascular-kidney-metabolic diseases in the UK biobank: influences of night shift work, sleep duration, and chronotype",
  "uid": "54e89053-4562-551d-ba7a-a4bf57236485"
}