{
  "abstract": "Objective The EPHOR project (2020–2025) aims to move beyond the conventional ‘one exposure – one outcome’ paradigm by investigating complex working-life exposures in relation to a wide range of non-communicable diseases (NCDs). The goal is to lay the groundwork for cost-effective evidence-based prevention by generating: (i) Improved knowledge on how multiple exposures in the working-life exposome relate to NCDs, and; (ii) Innovative methods for collecting, storing, and interpreting exposome data in occupational settings.Material and Methods The project combines in-depth exposome investigations in two case studies: night shift work and respiratory disease with large-scale analyses of existing cohorts. New methods were developed to assess both external (e.g. sensor-based) and internal (e.g. noninvasive biological sampling) exposures. For cohort-based analyses, efforts included a comprehensive inventory of European cohorts, development of a harmonized job exposure matrix (EuroJEM), and methods for handling multiple exposures.Results This presentation concludes the symposium by summarizing key lessons learned and outlining future prospects. A major achievement was demonstrating the feasibility—but also the complexity—of combined analyses across multiple existing cohorts as well as of using intensive measurement approaches to collect new exposome data. With respect to using existing cohorts, harmonization of methods and data is essential for producing meaningful results. These efforts can be complemented by smaller, targeted exposome studies that use intensive but feasible measurement approaches to test findings from cohorts and generate new hypotheses to be evaluated in larger datasets. This bidirectional strategy is a key recommendation. The EPHOR We-Expose Toolbox—developed for researchers, policymakers, and occupational health practitioners—as a resource for applying exposome approaches in occupational Health, will also be introduced.Conclusion The EPHOR project highlights that while exposome research in occupational settings is complex, it can be feasible and informative. The tools and lessons from this project offer valuable guidance for shaping future occupational health research and policy.",
  "authors": [
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Anjoeka Pronk"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Miranda Loh"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Maria Albin"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Jenny Selander"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Lode Godderis"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Manosij Ghosh"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Roel Vermeulen"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Susan Peters"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Ingrid S Mehlum"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Michelle C Turner"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Vivi Schlünssen"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Barbara Harding"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Svetlana Solovieva"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Tina Garani-Papadatos"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Martie Van Tongeren"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Eelco Kuijpers"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Jorunn Kirkeleit"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Wenxin Wan"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Anne Mette Lund Würtz"
    },
    {
      "affiliations": [
        "TNO, Netherlands. IOM, UK. Karolinska, Sweden. KU Leuven, Berlgium. Utrecht University, Netherlands. STAMI, Norway. ISGlobal, Spain. Aarhus University, Denmark. FIOH, Finland. PDA, Greece. Manchester University, UK"
      ],
      "name": "Manolis Kogevinas"
    }
  ],
  "title": "8288227 The EU exposome project for health and occupational research (EPHOR): overall experiences, lessons learnt and future prospects",
  "uid": "5061f0d1-4775-5e47-818c-b6208c5b9d17"
}