{
  "abstract": "Objective Chemical occupational exposures are established risk factors for chronic obstructive pulmonary disease (COPD), but most evidence comes from studies that overlook the potential impact of multiple co-exposures. The occupational exposome framework addresses this by capturing a broad range of occupational exposures across a career. We aimed to explore the association between the occupational exposome and COPD risk.Material and Methods We included individuals aged ≥40 years without COPD at baseline from four registry-based cohort studies: the Danish Occupational Cohort with eXposure data (DOC*X), the Swedish National Cohort on Work and Health (SNOW), the State of Labor Force in Finland (SLFF) cohort, and the Norwegian Nor-Work cohort. Participants were followed from cohort-specific start years between 1960 and 1990 through to 2022. Occupational histories were coded using the European version of the International Standard Classification of Occupations 1988 (ISCO-88 (COM)). Cumulative exposures were assigned via job-exposure matrices (EuroJEM, OAsJEM, Endo-JEM, ALOHA+ JEM, and DOM-JEM), collectively covering 52 chemical, psychosocial, and ergonomic factors. Incident COPD was identified from hospital records with a primary or secondary diagnosis of COPD (ICD-10 code J44) or emphysema (J43). In the ExWAS analysis, we used discrete-time hazard models to assess associations between individual exposures and incident COPD. Model 1 was adjusted for age, sex, and smoking status; model 2 included additional adjustment for education. These were followed by mutually adjusted LASSO regression to identify the most relevant exposures.Results Analyses are ongoing and are expected to reveal individual occupational exposures and co-exposure patterns associated with increased COPD risk.Conclusion This study is expected to improve our understanding of how complex occupational exposure patterns across working-life relate to COPD risk, offering insights that may inform future prevention strategies.",
  "authors": [
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Tosca de Crom"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Theresa Kynde"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Wenxin Wan"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Claudia Lissåker"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Jenny Selander"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Pernilla Wiebert"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Henrik Kolstad"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Jorunn Kirkeleit"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Ingrid Sivesind Mehlum"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Karina Undem"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Svetlana Solovieva"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Ioannis Basinas"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Hans Kromhout"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Michelle C Turner"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Anjoeka Pronk"
    },
    {
      "affiliations": [
        "Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands. Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark. Department of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. National Institute of Occupational Health (STAMI), Oslo, Norway. Finnish Institute of Occupational Health, Helsinki, Finland. Centre for Occupational and Environmental Health, School of Health Science, University of Manchester, Manchester, UK. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain"
      ],
      "name": "Vivi Schlünssen"
    }
  ],
  "title": "8285318 Occupational exposome and the risk of COPD",
  "uid": "4c97c29e-c1fb-52c4-bef5-b86aa8b4a7c5"
}