{
  "abstract": "Objective Alternating around-the-clock work schedules disrupt the natural circadian rhythms, resulting in circadian misalignment that increases risks for metabolic and cardiovascular diseases. How night shift work affects glycemic profiles in real-world settings remains to be settled. We hypothesized that working during the night impairs glucose levels among female hospital employees compared to shift work during the day.Material and Methods The study employs an observational design in which a subgroup of the 1001 nights-cohort in Denmark of 57 female hospital employees without known diabetes were found eligible to register working hours, sleep, and food intake in diaries while wearing a Continuous Glucose Monitor (CGM, Dexcom) for seven days. A night shift was defined as working 8 hours from 23:00 to 07:00, and a day shift as working 8 hours from 07:00 to 15:00. A ‘night off’ and a ‘day off’ were defined as not working during these intervals. The study included 39 participants, each having (1) at least one night shift and off night and/or (2) at least one day shift and off day. Thirty-five participants had both. Daily mean and standard error of glucose levels at night and day shifts and at off nights and days were calculated.Results Participants completed a total of 76 night shifts and 276 nights off, along with 72 day shifts and 246 days off. The mean glucose levels were 116.0 (SEM 1.9) mg/dL during night shifts, 113.2 (SEM 0.9) mg/dL during nights off, 111.7 (SEM 1.6) mg/dL during day shifts, and 111.7 (SEM 1.0) mg/dL during days off.Conclusion Shift work may modestly increase mean glucose levels at night but not at daytime. Results of other CGM-derived outcome variables and ongoing statistical variance component modeling using the within-person design will be presented at the conference.Funding The Danish Working Environment Research Fund (26202009; 19202209), The Health Foundation (22B0452), the European Union’s Horizon (# 874703), NFA, and The Danish Cardiovascular Academy.",
  "authors": [
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Rasmus Reeh"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Anders Aagaard"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Nanna Lind"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Jannet Svensson"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Thomas Mandrup-Poulsen"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Kirsten Nabe-Nielsen"
    },
    {
      "affiliations": [
        "The National Research Centre for the Working Environment, Copenhagen, Denmark. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Data Science, IT University of Copenhagen, Copenhagen, Denmark. Department of Diabetes Care, Steno Diabetes Center Copenhagen, Denmark. Clinical and Translational Research, Diabetes Technology, Steno Diabetes Center Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Anne Helene Garde"
    }
  ],
  "title": "8290977 Night shift work may impair glucose levels at night: a field study among female hospital employees",
  "uid": "49f22cb0-643d-55fc-b39e-de69759178d7"
}