{
  "abstract": "Objective The impact of multiple occupational exposures on short-term changes in lung function has barely been investigated. In a subsample of the population-based, multicenter ECRHS study, we included persons with a job and mild respiratory symptoms. We aimed to investigate the association between the working-life exposome and cross-week changes in lung function (∆FEV1, ∆FVC and ∆FEV1/FVC).Material and Methods During a workweek, we used the EPHOR sensor system to sample personal high temporal resolution data for physical activity, sleep, temperature, light, UVB radiation, humidity, particle count, PM1, PM2.5, PM10, and noise. Personal exposure to environmental volatile organic compounds and endotoxin levels at home were assessed during the week. At the beginning and end of the workweek, metals (urine and blood), cotinine (blood) and polycyclic aromatic hydrocarbons (urine) were measured, and lung function measurements were conducted. Correlation analysis and machine learning approaches are used to identify exposures important to lung function changes. The selected exposures and clusters are investigated individually and combined in relation to cross-week changes in lung function, and different exposure metrics (e.g. mean, peaks).Results Analyses are ongoing and will be presented at the conference. Among 139 participants (47% females), the mean age was 59 years, and 9% were current smokers. A total of 51% held administrative/office jobs, 37% service/sales jobs, while 12% were manual workers. Overall, we observed a slight decrease in lung function during the workweek. The mean (SD) changes were ∆FEV1 = -25 (166)mL, ∆FVC = -3.1 (207)mL, and ∆FEV1/FVC = -0.0057 (0.025), with only minor differences between the three job groups.Conclusion Preliminary findings point to a slight cross-week decline in lung function, with considerable individual differences. This study will help disentangle the complex relationship between the short-term working-life exposome and respiratory impairment by considering the multitude of exposures, their temporality and relative importance.Funding This project is part of the Exposome Project for Health and Occupational Research (EPHOR) funded by EU’s Horizon 2020, grant agreement number 874703.",
  "authors": [
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Anne Mette Lund Würtz"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Jorunn Kirkeleit"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Sander Ruiter"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Eugenio Traini"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Fiona Carson"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Miranda Loh"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Will Mueller"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Manosij Ghosh"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Evi De Ryck"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Cecilie Svanes"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Toril Mørkve Knudsen"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Theresa Møller Kynde"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Kirsten Østergaard"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Christer Janson"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Andrei Malinovschi"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Lars Modig"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Mathias Holm Rain Jogi"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Þórarinn Gíslason"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Judith García-Aymerich"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Victoria Alcaraz-Serrano"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Anjoeka Pronk"
    },
    {
      "affiliations": [
        "Aarhus University Public Health. University of Bergen, Bergen, Norway. STAMI, Oslo, Norway. TNO, Utrecht, The Netherlands. Utrecht University, Utrecht, The Netherlands. IOM, Edinburgh, UK. KU Leuven, Leuven, Belgium. Haukeland University Hospital, Bergen, Norway. Uppsala University, Uppsala, Sweden. Umeå University, Umeå, Sweden. University of Gothenburg, Gothenburg, Sweden. University Hospital, Lung Clinic, Tartu, Estonia. The National University Hospital of Iceland, Reykjavik, Iceland. Barcelona Institute for Global Health, Barcelona, Spain"
      ],
      "name": "Vivi Schlünssen"
    }
  ],
  "title": "8283394 Short-term working-life exposome and cross-week changes in lung function among persons with (mild) respiratory symptoms",
  "uid": "3afc5084-39b8-5795-a1be-68c31eb0dbae"
}