{
  "abstract": "Objective Night-shift work is known to disrupt circadian rhythms, potentially leading to adverse health effects. This study investigated the relationship between sleep timing and cortisol secretion profiles among female hospital employees.Material and Methods 89 female hospital workers (68 shift workers, 21 non-shift workers) were included in this cross-sectional study. Shift workers worked rotating shifts, including night shifts, whereas non-shift workers maintained regular day shifts. Shift workers provided salivary cortisol samples collected at multiple time points during two consecutive day shifts and three consecutive night shifts. Non-shift workers collected their samples across two consecutive day shifts. Sleep timing was assessed through polysomnography and sleep diaries. Using generalized additive mixed models, we estimated shift-specific cortisol curves, considering the non-linear relationship between time since waking up and logarithmized cortisol levels, adjusted for age, chronotype, menopausal status, contraceptive use, stress load, smoking status. Each cortisol curve was summarized by cortisol awakening response (CAR), peak-to-bed slope, and total cortisol output.Results Shift workers on night shifts showed a flattened U-shaped cortisol profile after the post-awakening peak, with peak-to-bed slope close to zero (-0.02, 95%-CI = -0.82, 0.78). In the same women, a normal diurnal cortisol profile with a steep negative peak-to-bed slope after the post-awakening peak (-2.57, 95%-CI = -3.17, -1.98) was observed on day shifts. Day-shift cortisol curves were similar in shape for both, shift workers and non-shift workers, showing differences in mean cortisol levels at waking up (-0.41 log(nmol/L), 95%-CI = -0.79, -0.02) and in CAR (0.37 log(nmol/L), 95%-CI = 0.10, 0.63).Conclusion This study in female shift workers showed night-work associated circadian misalignment between timing of sleep and cortisol rhythm. These findings highlight the importance of considering circadian biology in occupational health, particularly for professions requiring night work.",
  "authors": [
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Katarzyna Burek"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Sylvia Rabstein"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Thomas Kantermann"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Céline Vetter"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Rui Wang-Sattler"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Martin Lehnert"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Dirk Pallapies"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Karl-Heinz Jöckel"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Thomas Brüning"
    },
    {
      "affiliations": [
        "Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bochum, Germany. Institute for Labor and Personnel (IAP), University of Applied Sciences for Economics and Management (FOM), Essen, Germany. SyOpus, Bochum, Germany. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany"
      ],
      "name": "Thomas Behrens"
    }
  ],
  "title": "8288908 Altered coordination between sleep timing and cortisol profiles in night-working female hospital employees",
  "uid": "0f3a4a8b-53ca-5554-89ea-efd667a2225a"
}