{
  "abstract": "Objective Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. Emerging evidence suggests that exposure to nanomaterials and ultrafine particles (UFP) may alter cardiovascular function and contribute to the burden of CVD. Such exposures often occur in occupational settings involving nanomaterial production or high-energy processes like welding, printing, machining, and combustion. However, the cardiovascular effects of occupational exposure to nanomaterials and UFP remain poorly characterized, posing challenges for (occupational) health professionals. To summarize the existing evidence on cardiovascular health effects associated with occupational exposure to nanomaterials and UFP, identify commonly used biomarkers and diagnostic techniques, and highlight knowledge gaps requiring further investigation.Material and Methods A comprehensive search was conducted in MEDLINE, EMBASE, and Web of Science from inception to April 2024. Studies were eligible if they assessed health outcomes among workers exposed to nanomaterials or UFP in occupational settings. A total of 6020 unique records were screened, of which 66 studies met the inclusion criteria. Of these, 16 studies reported cardiovascular outcomes.Results The included studies employed various designs, with the majority being cross-sectional (n=11). Common workplace exposures included carbon nanotubes/fibers, titanium dioxide, and UFP from various industrial processes. The most frequently studied outcomes were cardiovascular inflammation and function. Reported biomarkers included elevated levels of VCAM-1, ICAM-1, endothelin-1, and hs-CRP. Some studies also reported changes in metabolic markers and vascular function; however, findings related to clinical measures such as blood pressure, heart rate variability, and autonomic function were inconsistent.Conclusion Occupational exposure to nanomaterials and UFP may be associated with early alterations in cardiovascular function. However, evidence on specific functional or structural disorders remains limited. This review highlights the need for longitudinal studies with detailed exposure assessment and standardized diagnostic tools to better understand causal pathways and inform occupational health policy.",
  "authors": [
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Ali Dehghani"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Sylvia HJ Jochems"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Yvette Christopher-de Vries"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Maartje Brouwer"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Susan Peters"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Frederieke Schaafsma"
    },
    {
      "affiliations": [
        "Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam. Institute for Risk Assessment Sciences. RIVM. Institute of Occupational Medicine, Edinburgh, UK"
      ],
      "name": "Gilbert Wijntjens"
    }
  ],
  "title": "8287225 Cardiovascular health effects of occupational exposure to nanomaterials and ultrafine particles: a scoping review",
  "uid": "047ed560-e8b4-5c2b-a0ed-67995c1cabcb"
}