{
  "abstract": "Background Mechanical thrombectomy (MT) is standard of care for acute ischemic stroke (AIS) due to large vessel occlusion. While stent retriever thrombectomy (SRT) and aspiration thrombectomy are widely used, comparative evidence on newer aspiration systems like the Route 92 FreeClimb catheter and Tenzing-assisted delivery of aspiration (TADA) remain limited. This study compared procedural efficiency, recanalization success, and clinical outcomes between the Route 92 TADA system and SRT.Methods This retrospective single-center cohort study included 163 adult patients with AIS treated with MT between September 2021 and January 2025. Patients were grouped by primary MT technique (TADA vs. SRT ). Propensity score matching (PSM) was performed to control for baseline differences. Outcomes included puncture-to recanalization time (PTR), first-pass recanalization (FPR), final Thrombolysis in Cerebral Infarction (TICI) score, symptomatic intracranial hemorrhage (sICH), 90-day modified Rankin Scale (mRS), and mortality.Results After PSM, 70 matched pairs were analyzed. TADA demonstrated a shorter median PTR (20 vs. 25 minutes; p=0.0088) and higher FPR for TICI 2c-3 (97.4% vs. 69.2%; p=0.001) and TICI 3 (81.6% vs. 55.3%; p=0.014). Final recanalization rates (TICI ≥2c) were also superior with TADA (94.3% vs. 69.1%; p<0.001). Clinical outcomes, including favorable 90-day mRS, mortality, and sICH, did not significantly differ.Conclusions The Route 92 TADA system improves procedural efficiency and recanalization compared with SRT. However, these advantages did not translate into improved clinical outcomes. Prospective studies are warranted to validate these findings and define the clinical role of TADA in stroke care.Disclosures J. Granstein: 2; C; Johnson&Johnson/Cerenovus (ended 2024). E. Mensah: None. S. Purohit: None. P. Bhatt: None. A. Jokhio: None. N. Arunachalam Sakthiyendran: None. P. Taussky: None. C. Ogilvy: None.",
  "authors": [
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "J Granstein"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "E Mensah"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "S Purohit"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "P Bhatt"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "A Jokhio"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "N Arunachalam Sakthiyendran"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "P Taussky"
    },
    {
      "affiliations": [
        "Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA"
      ],
      "name": "C Ogilvy"
    }
  ],
  "title": "E-295 Comparison of procedural efficiency, technical success, and clinical outcomes of the route 92 aspiration system and stent-retriever thrombectomy",
  "uid": "ef9843ef-e5e9-58b0-817c-ac1a6f32e666"
}