{
  "abstract": "Introduction The ReSolv™ stent is a novel partially bioresorbable flow-diverting stent made from a combination of metal and polymeric strands. The polymeric component may result in improved neointima formation and endothelialization compared to all-metal stents, but the healing response of a polymeric stent has not yet been characterized. In this study, we evaluate the ReSolv™ stent in an animal model compared to a metal flow diverter.Methods ReSolv™ and metal flow-diverting stents were implanted into carotid arteries and brachiocephalic arteries in a rabbit model. Optical coherence tomography (OCT) and digital subtraction angiography (DSA) were performed at 48 hours followed by termination. Additional animals implanted with the ReSolv stent were terminated at 7 days, 1 and 3-months post-stenting. Endothelization and neointima formation were evaluated and scored using established histological scoring systems.Results OCT demonstrated improved neointima formation over the ReSolv™ stent compared to the fully metal flow-diverting stent at 48h. Histological data suggested preferential coverage over the polymer strands of the ReSolv™ stent compared to both the metal strands of the ReSolv™ stent and the metal flow diverter. The ReSolv™ stent was fully endothelialized at the 7-day, 1-month, and 3-month termination timepoints.Conclusions ReSolv™, a hybrid polymer-metal flow-diverting stent, has the potential to lead to faster endothelialization and neointimal coverage compared to fully metal stents which may result in improved aneurysm occlusion rates and safety. Longer term animal studies and early human clinical evaluations are ongoing.Disclosures A. Mitha: 2; C; Stryker Neurovascular, Microvention. 4; C; Fluid Biomed Inc. J. Wong: 4; C; Fluid Biomed Inc.",
  "authors": [
    {
      "affiliations": [
        "University of Calgary, Calgary, AB, Canada"
      ],
      "name": "A Mitha"
    },
    {
      "affiliations": [
        "Neurosurgery, University of Calgary, Calgary, AB, Canada"
      ],
      "name": "J Wong"
    }
  ],
  "title": "E-267 Endothelialization of the ReSolv™ stent in a rabbit model",
  "uid": "ee480360-ba2a-5320-baaf-6d645291b975"
}