{
  "abstract": "Introduction Temporalis muscle thickness (TMT) is a marker for sarcopenia and is shown to correlate well with pre-morbid frailty. We aimed to explore its association with post-thrombectomy clinical outcomes in patients with large strokes.Methods In a secondary analysis of SELECT2 trial, all EVT patients with available and technically evaluable non-contrast CT were included. TMT was measured independently by 2 neuroradiologists using axial multiplanar reconstruction. Sex-specific lowest quartile thresholds (5.37mm for males, 3.78mm for females) were used to dichotomize patients into low vs normal TMT. Association of TMT status with functional and safety outcomes at 90-day follow-up was explored using appropriate regression models - adjusted for age, time from last-known-well to procedure, stroke severity at presentation, CT ASPECTS, ischemic core volume, successful reperfusion status and anesthesia modality.Results Of 180 patients who received EVT, TMT was measured in 176 patients with technically evaluable non-contrast CTs, with median (IQR) TMT of 5.08 (3.78-6.04) mm in 71 females and 6.42 (5.37-7.76) mm in 105 males. Using pre-specified sex-specific thresholds, 45 (27 males, 18 females) were determined to have low TMT. Low TMT was independently associated with worse mortality at 90-day (low TMT: 51% vs normal TMT: 34%, aRR: 1.53, 95% CI: 1.10 to 2.12, p-value: 0.011) and 1-year follow-up (low TMT: 51.1% vs normal TMT: 33.8%, aRR: 1.40, 95% CI: 1.02 to 1.91, p-value: 0.036), and higher incidence of 1-year mRS 5-6 (low TMT: 65.1% vs normal TMT: 48.8%, aRR: 1.34, 95% CI: 1.02 to 1.76, p-value: 0.036). A trend towards worse mRS scores at 90d (low TMT: 6 (3,6) vs normal TMT: 4 (3,6), aGenOR: 0.73, 95% CI: 0.50 to 1.05, p-value: 0.086), and worse mRS 5-6 at 90-day follow (low TMT: 57.8% vs normal TMT: 43.1%, aRR: 1.32, 95% CI: 0.99 to 1.77, p-value: 0.055). Differences in mRS 0-2 (low TMT: 17.8% vs normal TMT: 21.5%, aRR: 0.81, 95% CI: 0.42 to 1.56, p-value: 0.522 at 90d or 23.3% vs 24.0%, aRR: 0.92, 95% CI: 0.48 to 1.77, p-value: 0.802 at 1-year f/up) or mRS 0-3 (low TMT: 28.9% vs normal TMT: 40.8%, aRR: 0.75, 95% CI: 0.49 to 1.16, p-value: 0.200 at 90d or 32.6% vs 39.2%, aRR: 0.84, 95% CI: 0.53 to 1.34, p-value: 0.466 at 1-year f/up) did not reach statistical significance.Conclusions Low TMT was not associated with decreased functional independence or independent ambulation in EVT patients with large core strokes but was associated with higher mortality.Disclosures A. Radaideh: None. S. Ansari: None. D. Pujara: None.Abstract E-319 Figure 1Distribution of modified rankin scale scores at 90-day follow-up among patients receiving EVT, stratified based on temporalis muscle thicknessAbstract E-319 Table 1Functional outcomes at 90-day and 1-year follow-up across patients with low vs normal temporalis muscle thickness. All models were adjusted for age, NIHSS, time to procedure, CT ASPECTS, ischemic core volume, successful reperfusion (mTICI 2b-3) and type of anesthesia",
  "authors": [
    {
      "affiliations": [
        "Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL"
      ],
      "name": "A Radaideh"
    },
    {
      "affiliations": [
        "Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL"
      ],
      "name": "S Ansari"
    },
    {
      "affiliations": [
        "Neurology, UH Cleveland Medical Center, Cleveland, OH"
      ],
      "name": "D Pujara"
    },
    {
      "affiliations": [
        "Rush, Chicago, IL"
      ],
      "name": "M Chen"
    },
    {
      "affiliations": [
        "University of Texas at Houston, Houston, TX"
      ],
      "name": "A Sarraj"
    }
  ],
  "title": "E-319 Association of temporalis muscle thickness with outcomes following endovascular thrombectomy in large core strokes: a SELECT2 analysis",
  "uid": "ccf0b2d1-9d99-5c13-93fd-15f6af42d005"
}