{
  "abstract": "Background The DISTALS randomized trial evaluates the safety and effectiveness of the TIGERTRIEVER-13 Revascularization Device, a radially-adjustable stent-retriever designed for deployment in distal medium vessel occlusions (DMVO). Early (24h) outcome results were presented at ISC (February-2026); full, results, including 3-month outcomes, will be presented at SNIS-2026.Methods DISTALS is a US/Europe, multicenter, prospective, randomized, blinded endpoint, FDA IDE trial in patients ineligible for IV thrombolysis. Trial objective is to evaluate Tigertriever-13 safety/effectiveness in restoring blood flow in DMVO patients presenting within 24h of onset. The primary outcome is successful reperfusion (24h CTP/PWI-MR) without symptomatic intracranial hemorrhage (sICH). Clinical efficacy/safety secondary outcomes include 90d global disability (mRS shift), the EQ-5D, MoCA, mortality and any ICH.Results Between May 2022 and December 2025, 149 patients were enrolled, 31 lead-in and 118 randomized. Mean age was 69 (±11); 39%-women; region US 68%-US, EU-32%; baseline NIHSS 7.3 (±4.5). Occlusion locations were: non-/co-dominant M2-41%; M3-25%; PCA-25%; ACA-9%. LKWT-to-randomization was 511 minutes (IQR 245-884). The primary endpoint, successful reperfusion without sICH, favored the treatment arm, 86.3% vs. 27.7%, p<0.001. sICH events were 1.6% vs 0% (p=1), ITT, with 0 sICH in randomized patients treated with Tigertriever-13. The last patient 3-month follow-up will be completed in March 2026, allowing trial mRS, EQ-5D, MoCA, and mortality results to be presented at ESOC.Conclusion Early outcome results of the DISTALS trial demonstrate that the Tigertriever-13 is a safe and effective clot removal treatment strategy for DMVO patients. Clinical endpoint results will provide important additional insights into treatment outcomes.Disclosures A. Siddiqui: None. J. Saver: None. R. Chapot: None.",
  "authors": [
    {
      "affiliations": [
        "Neurosurgery, University of Buffalo, Buffalo, NY"
      ],
      "name": "A Siddiqui"
    },
    {
      "affiliations": [
        "UCLA Comprehensive Stroke, Los Angeles, NY"
      ],
      "name": "J Saver"
    },
    {
      "affiliations": [
        "WMG Neurosurgery, Wellstar Health System, Marietta, GA"
      ],
      "name": "R Gupta"
    },
    {
      "affiliations": [
        "Erasme Hospital, Brussels, Belgium"
      ],
      "name": "A Guenego"
    },
    {
      "affiliations": [
        "Neurology, UTSCHSA Valley Baptist, Harlingen, TX"
      ],
      "name": "A Hassan"
    },
    {
      "affiliations": [
        "Pittsburgh, PA"
      ],
      "name": "A Jadhav"
    },
    {
      "affiliations": [
        "Vascular Neurology of Southern California, Thousand Oaks, CA"
      ],
      "name": "M Taqi"
    },
    {
      "affiliations": [
        "Galaxy Therapeutics, Inc, Milpitas, CA"
      ],
      "name": "OO Zaidat"
    },
    {
      "affiliations": [
        "University of California, Los Angeles, Los Angeles, CA"
      ],
      "name": "D Liebeskind"
    },
    {
      "affiliations": [
        "SUNY SB, Stony Brook, NY"
      ],
      "name": "D Fiorella"
    },
    {
      "affiliations": [
        "Alfried-Krupp-Hospital, Essen, Germany"
      ],
      "name": "R Chapot"
    }
  ],
  "title": "O-004 Final results of the DISTALS (distal ischemic stroke treatment with adjustable low-profile stentriever) randomized trial of tigertriever 13-EVT for DMVO",
  "uid": "abb2ccd1-4533-5a34-b22d-78f145c06baf"
}