{
  "abstract": "Introduction/Purpose There has been increased interest in leveraging neurointerventional techniques to develop the intersection between neuroendovascular and functional neurosurgery, such as transvenous electroencephalopgraphy (EEG) via the Stentrode. Such devices, however, are often limited to large vessels given their inherent size. This study is a preliminary assessment of a microfabricated transvenous electrode array (‘µTV-EEG’) designed for endovascular EEG in small caliber, distal vasculature.Materials and Methods The µTV-EEG consists of a Parylene C polymer-based structural backbone arranged as a strip electrode array and attached to a microwire. There are 7 platinum recording electrodes along the device, ranging in size from a group of eight connected 200 µm electrodes (TV-1) to a single 100 µm electrode (TV-7). The µTV-EEG was placed into the superior sagittal sinus of an anesthetized Ovis Aries sheep under fluoroscopic guidance. A subdural grid (‘grid’) and stereotactic depth electrode (consisting of both ‘macro’ and ‘micro’ electrodes) were also placed (figure 1A). Signals were simultaneously recorded from all electrodes. Intrinsic characteristics of each electrode were evaluated. Individual electrodes were compared using Pearson correlation coefficient (PCC) and variance accounted for (VAF). Group/device-level comparisons were performed using Relevance-Balanced Continuum Correlation Analysis (ReBaCCA). ‘Non-inferiority’ was defined a priori as R>0.70.Results A total of 1323.1 seconds of signal was obtained from each electrode (7 µTV-EEG, 4 grid, 6 macro, 3 micro). The recording had a burst suppression pattern; 1208.2 seconds were baseline/isoelectric signal and 33.0 seconds were intermittent burst patterns (198 total bursts). Burst patterns were treated as ‘true’ signal, whereas isoelectric patterns (excluding artifact) were considered baseline noise. The µTV-EEG had smaller but similar mean signal power (12114 µV 2) to the other devices (grid: 14858 µV2, macro: 21395 µV2, micro: 37885 µV2), but a notably lower mean SNR (µTV-EEG: 21.7, grid: 598.9, macro: 626.9, micro: 266.2). However, PCC showed high correlation between nearly all electrode types (figure 1B). In particular, µTV-EEG showed high correlation with the nearest adjacent electrodes, including Grid-6 (R=0.939-0.975) and Macro-6 (R=0.947-0.985). Following ReBaCCA, the µTV-EEG was non-inferior to both the grid (R=0.839) and macro electrodes (R=0.720), but not the micro electrodes (R=0.693).Conclusion The µTV-EEG showed high correlation with other standard invasive EEG devices. Further testing is needed to investigate device performance in small, deeper vasculature and with more complex EEG patterns. These results serve as an initial proof of concept and highlight the unique role that endovascular neurosurgery could play in traditionally ‘non-vascular’ realms.Disclosures J. Dallas: 1; C; AANS/CNS Cerebrovascular Section. X. Zhang: None. H. Xu: None. B. Thielen: None. C. Liu: None. W. Mack: 2; C; Viseon, Imperative Care, Q’Apel, Medtronic, Stryker, Stream Biomedical, Spartan Micro, Egret. 4; C; Q’ Apel, Endostream, Viseon, Stream Biomedical, Spartan Micro, Radical Catheters, Vastrax, Borvo. E. Meng: None. P. Selvan: None. D. Song: None.Abstract O-042 Figure 1",
  "authors": [
    {
      "affiliations": [
        "Department of Neurological Surgery, University of Southern California, Los Angeles, CA"
      ],
      "name": "J Dallas"
    },
    {
      "affiliations": [
        "Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA"
      ],
      "name": "X Zhang"
    },
    {
      "affiliations": [
        "Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA"
      ],
      "name": "H Xu"
    },
    {
      "affiliations": [
        "Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA"
      ],
      "name": "B Thielen"
    },
    {
      "affiliations": [
        "Department of Neurological Surgery, University of Southern California, Los Angeles, CA"
      ],
      "name": "C Liu"
    },
    {
      "affiliations": [
        "Department of Neurological Surgery, University of Southern California, Los Angeles, CA"
      ],
      "name": "W Mack"
    },
    {
      "affiliations": [
        "Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA"
      ],
      "name": "E Meng"
    },
    {
      "affiliations": [
        "Lundquist Institute for Biomedical Innovation, Torrance, CA"
      ],
      "name": "P Selvan"
    },
    {
      "affiliations": [
        "Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA"
      ],
      "name": "D Song"
    }
  ],
  "title": "O-042 Intracranial electroencephalography using a microfabricated endovascular device: preliminary results in an ovis aries model",
  "uid": "19aa3fde-0e83-588e-b22c-8e8415a4472c"
}