{
  "abstract": "Introduction Intrasaccular devices (ISDs) represent an emerging strategy for wide-neck intracranial aneurysms, particularly when stent-assisted techniques are limited by anatomical constraints or antiplatelet requirements. Artisse 2.0 device incorporates a flare-shaped dual-layer nitinol mesh designed to optimize neck coverage and intra-aneurysmal flow disruption. We aimed to synthesize current early clinical outcomes and technical considerations relevant influencing device performance in neurointerventional practice.Methods A literature review was conducted using PubMed, Scopus and Web of Science. Search terms were ‘Artisse 2’, ‘New Artisse’, ‘Artisse 2.0’, ‘aneurysm*’ AND (‘intracranial’ OR ‘brain’ OR cerebrovascular). Included studies were selected based on clinical relevance. Duplicate (overlapping) cohorts were consolidated by including the most complete dataset. A qualitative synthesis of clinical outcomes and procedural parameters was performed.Results Five studies were included: one prospective registry (n=87), one multicenter series (n=23), one single-center study (n=26), one technical report, and one case report. Artisse 2.0 was primarily used in small (3–6 mm), saccular aneurysms, predominantly at bifurcation sites (78.3%), most commonly ACom and MCA. In the INSPIRE-A registry, implantation success was 96.6% (84/87), with complete occlusion (RROC I) in 80.0% (n=35) at 6 months, no retreatment, and favorable functional outcomes (mRS ≤1 in 92.2%). In Austrian multicenter experience (n=23), complete occlusion was 66.7% (12/18) at day 1, increasing to 81.3% (13/16) at ≥3 months, with adequate occlusion (RROC I–II) in 87.5% and no retreatment. Thromboembolic events occurred in 8.7% (2/23), all asymptomatic, with no hemorrhagic complications. Technical analyses demonstrated that devic sizing is a primary determinant of outcome. A morphology-driven, height-preserving sizing strategy improved neck coverage rates, with lower degrees of oversizing and reduced height loss. Spherical aneurysms tolerated a ‘+1/−1’ strategy, while cylindrical morphologies benefited from ‘+1/−0’ sizing. Optimal deployment requires confirmation of dome filling, neck apposition, and intra-aneurysmal stasis, with readiness for resheathing if suboptimal configuration is observed. Post-treatment device shape modification may occur without loss of occlusion, suggesting that structural changes may reflect intra-device thrombosis and healing rather than mechanical instability.Conclusions Artisse 2.0 demonstrates technical success and favorable occlusion rates in small wide-neck aneurysms. Outcomes are primarily driven by morphology-driven sizing, preservation of device height, and real-time reassessment of neck coverage and stasis. These findings support its use as a ISD in selected bifurcation aneurysms, potentially reducing the need for adjunctive techniques and prolonged antiplatelet therapy. However, longer-term independent validation and comparative studies remain necessary.Disclosures A. Carrión Cuéllar: None.Abstract O-065 Table 1Baseline characteristics of studies includedAbstract O-065 Table 2Clinical outcomes of included studies",
  "authors": [
    {
      "affiliations": [
        "Unitat Docent Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain"
      ],
      "name": "A Carrión Cuéllar"
    },
    {
      "affiliations": [
        "Hospital Higos Urco I, Chachapoyas, Peru"
      ],
      "name": "EL Cuéllar Jáuregui"
    }
  ],
  "title": "O-065 Artisse 2.0 for intracranial aneurysms: early clinical outcomes and technical determinants of device performance",
  "uid": "0cdc0854-091f-5c5d-8f4e-b22ff440f229"
}