{
  "abstract": "Background and objectives The outcomes of carotid artery stenting (CAS) for asymptomatic patients aged ≥80 years remain unclear. This study aimed to investigate the procedural and functional outcomes of CAS in these patients.Methods This was a post-hoc analysis of a nationwide retrospective registry of patients with asymptomatic carotid artery stenosis who underwent CAS. The primary outcome was a composite of ischemic stroke and all-cause death. The secondary outcomes were ischemic stroke, all-cause death, acute occlusion, and acute myocardial infarction. Functional outcomes were assessed using the modified Rankin Scale (mRS). The outcomes were assessed 30 days post-procedure and compared between patients aged ≥80 years and <80 years.Results Overall, 4549 patients were evaluated. Pre-procedural mRS and the prevalence of ≥80% stenosis were higher in the ≥80-year-old group. Calcified lesions and high risk for carotid endarterectomy were more common in the ≥80-year-old group. No significant between-group differences were found in primary and secondary outcomes. However, the functional outcomes were significantly worse in the ≥80-year-old group, with a higher proportion of patients with worse mRS score (ie, decreasing at least one point) at follow-up (11.2% vs 5.0%; adjusted OR 2.24 (95% CI 1.66 to 3.02)).Conclusion CAS for asymptomatic carotid artery stenosis is associated with poorer 30-day functional outcomes in patients aged ≥80 years than in those aged <80 years, but the composite of ischemic stroke and all-cause death is not significantly different between the two age groups.",
  "authors": [
    {
      "affiliations": [
        "Neurosurgery, Iryo Hojin Seijinkai Shimizu Byoin, Kyoto, Japan"
      ],
      "name": "Fuminori Shimizu"
    },
    {
      "affiliations": [
        "Neurosurgery, Hyogo Medical University, Nishinomiya, Japan"
      ],
      "name": "Kazutaka Uchida"
    },
    {
      "affiliations": [
        "Neurosurgery, Hyogo Medical University, Nishinomiya, Japan"
      ],
      "name": "Manabu Shirakawa"
    },
    {
      "affiliations": [
        "Neurosurgery, Hyogo Medical University, Nishinomiya, Japan"
      ],
      "name": "Fumihiro Sakakibara"
    },
    {
      "affiliations": [
        "Neurology, National Cerebral and Cardiovascular Center, Suita, Japan"
      ],
      "name": "Satoru Fujiwara"
    },
    {
      "affiliations": [
        "Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Japan"
      ],
      "name": "Koji Iihara"
    },
    {
      "affiliations": [
        "Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Japan"
      ],
      "name": "Hirotoshi Imamura"
    },
    {
      "affiliations": [
        "Neurosugery, Juntendo University Hospital, Bunkyo-ku, Japan"
      ],
      "name": "Akira Ishii"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan"
      ],
      "name": "Yuji Matsumaru"
    },
    {
      "affiliations": [
        "Regulatory Science of Medical Device Development and Innovation, Kyoto University Graduate School of Medicine, Kyoto, Japan"
      ],
      "name": "Chiaki Sakai"
    },
    {
      "affiliations": [
        "Neurosurgery, Kindai University, Osaka-Sayama, Japan"
      ],
      "name": "Tetsu Satow"
    },
    {
      "affiliations": [
        "Neurosurgery, Hyogo Medical University, Nishinomiya, Japan"
      ],
      "name": "Shinichi Yoshimura"
    },
    {
      "affiliations": [
        "Neurosurgery, Iryo Hojin Seijinkai Shimizu Byoin, Kyoto, Japan"
      ],
      "name": "Nobuyuki Sakai"
    }
  ],
  "title": "Outcomes of carotid artery stenting in patients aged 80 years or older with asymptomatic carotid artery stenosis",
  "uid": "febad888-8f50-5b9a-b37c-61ad573a7627"
}