{
  "abstract": "Background To develop and validate a novel scoring system for predicting successful endovascular recanalization in patients with non-acute symptomatic carotid artery occlusion (NASCAO).Methods We analyzed consecutive patients from a nationwide prospective registry who underwent endovascular treatment for NASCAO. Patients were divided into derivation and validation cohorts based on the enrolling centers. Technical success was defined as Thrombolysis in Cerebral Infarction score 3 and <50% residual stenosis. A NASCAO score was developed using stepwise logistic regression based on the Bayesian information criterion. The performance of the score was examined in terms of discrimination and calibration.Results Among the 511 included patients, successful recanalization was achieved in 61.3% (192/313) of the derivation cohort and 54.5% (108/198) of the validation cohort. Four independent predictors of technical success were used to construct a 6-point NASCAO score: ischemic stroke (1 point), time from last event to intervention within 1–30 days (1 point), tapered proximal stump (1 point), and number of occluded segments (1–2: 3 points, 3–4: 2 points, 5–7: 0 points). The area under the receiver operating curve (AUC) of the NASCAO score was 0.780 (95% CI 0.729 to 0.832) in the derivation cohort and 0.758 (95% CI 0.692 to 0.824) in the validation cohort. Patients with a score of 4–6 had 6.3 times higher odds of successful recanalization than those with a score of 0–3 (95% CI 4.29 to 9.38, P<0.001).Conclusions The NASCAO score is a reliable tool for predicting successful endovascular recanalization in patients with NASCAO.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Shuxian Huo"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Chao Hou"
    },
    {
      "affiliations": [
        "Department of Geriatric Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Xuan Shi"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Qin Yin"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wannan Medical College, Wuhu, Anhui, China"
      ],
      "name": "Xianjun Huang"
    },
    {
      "affiliations": [
        "Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"
      ],
      "name": "Wen Sun"
    },
    {
      "affiliations": [
        "Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"
      ],
      "name": "Guodong Xiao"
    },
    {
      "affiliations": [
        "Department of Neurology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"
      ],
      "name": "Yong Yang"
    },
    {
      "affiliations": [
        "Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Hongbing Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"
      ],
      "name": "Min Li"
    },
    {
      "affiliations": [
        "Cerebrovascular Disease Treatment Center, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"
      ],
      "name": "Mingyang Du"
    },
    {
      "affiliations": [
        "Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"
      ],
      "name": "Yunfei Han"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Kang Yuan"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Wusheng Zhu"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China",
        "Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"
      ],
      "name": "Xinfeng Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Gelin Xu"
    },
    {
      "affiliations": [
        "Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China",
        "Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"
      ],
      "name": "Ruidong Ye"
    }
  ],
  "title": "A novel score to predict successful endovascular recanalization of non-acute carotid artery occlusion",
  "uid": "6fbde580-5d0f-5e63-a935-5d73ef654e23"
}