{
  "abstract": "Background Glenzocimab is a humanized fragment of a monoclonal antibody directed against the human platelet glycoprotein VI, which has shown promising features, including thrombus growth inhibition and minimal bleeding risk. The first inpatient study suggested the benefit of glenzocimab with alteplase in subgroups of patients with acute ischemic stroke (AIS) receiving endovascular treatment (EVT), with increased reperfusion rates and decreased risk of symptomatic hemorrhagic transformation. The objective of the GREEN (Glenzocimab for REperfusion in the setting of Endovascular therapy for brain infarctioN) study is to evaluate the efficacy of glenzocimab with EVT compared with EVT plus placebo, with or without intravenous thrombolysis (IVT), on functional outcome.Methods GREEN is a multicenter, randomized, double blind, placebo controlled study. Participants presenting with AIS and a large vessel occlusion of the anterior circulation (intracranial internal carotid artery or middle cerebral artery, or both), with symptoms onset within 24 hours, will be randomized to one of two groups: intravenous glenzocimab 1000 mg with standard of care (SoC-EVT±IVT) or SoC (EVT±IVT) plus placebo. The main primary efficacy endpoint is functional outcome (assessed by the modified Rankin Scale score) at 90 days.Conclusion This is the first randomized trial evaluating the efficacy of glenzocimab with EVT. This prospective trial aims to determine whether glenzocimab with EVT improves functional outcome.Trial registration ClinicalTrials.gov NCT05559398",
  "authors": [
    {
      "affiliations": [
        "Deparment of Neurology, Université Paris Cité, Institut Universitaire de France, GH Lariboisiere Fernand-Widal, Paris, France",
        "Departement of Interventional Neuroradiology, INSERM 1144, Fondation Rothschild Hospital, Paris, France"
      ],
      "name": "Mikaël Mazighi"
    },
    {
      "affiliations": [
        "Université Paris Cité, Paris, France",
        "Department of Statistics, APHP, Paris, France"
      ],
      "name": "Jerome Lambert"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France"
      ],
      "name": "Benjamin Gory"
    },
    {
      "affiliations": [
        "Department of Neurology, Fondation Rothschild Hospital, Paris, France"
      ],
      "name": "Pierre Seners"
    },
    {
      "affiliations": [
        "Department of Vascular Neurology, University Hospital of Toulouse, Toulouse, France"
      ],
      "name": "Lionel Calvière"
    },
    {
      "affiliations": [
        "Department of Neurology, Groupement Hospitalier Est Hôpital Pierre Wertheimer, Lyon, France"
      ],
      "name": "Tae Hee Cho"
    },
    {
      "affiliations": [
        "APHP, Paris, France"
      ],
      "name": "Agnès Aghetti"
    },
    {
      "affiliations": [
        "Department of Neurology, CHRU de Tours, Tours, France"
      ],
      "name": "Marco Pasi"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital of Tours, Tours, France"
      ],
      "name": "Gregoire Boulouis"
    },
    {
      "affiliations": [
        "Hospital Foch, Suresnes, France"
      ],
      "name": "Bertrand Lapergue"
    },
    {
      "affiliations": [
        "Hospital Foch, Suresnes, France"
      ],
      "name": "Arturo Consoli"
    },
    {
      "affiliations": [
        "Neurology, GHU Paris Psychiatrie et Neurosciences, Paris, France"
      ],
      "name": "Guillaume Turc"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France",
        "University of Limoges, CNRS, XLIM, UMR 7252, Limoges, France"
      ],
      "name": "Aymeric Rouchaud"
    },
    {
      "affiliations": [
        "Stroke Unit, Strasbourg University Hospitals, Strasbourg, France"
      ],
      "name": "Valerie Wolff"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, University Hospitals Strasbourg, Strasbourg, France",
        "Department of Interventional Radiology, Institut de Chirurgie Guidée par l’Image, Strasbourg, France"
      ],
      "name": "Raoul Pop"
    },
    {
      "affiliations": [
        "Stroke Unit, Assistance Publique Hopitaux de Marseille, Marseille, France"
      ],
      "name": "Laurent Suissa"
    },
    {
      "affiliations": [
        "Neurology Stroke Unit, University Hospital Centre Nancy, Nancy, France"
      ],
      "name": "Sébastien Richard"
    },
    {
      "affiliations": [
        "Department of Neurology, CHRU de Lille, Lille, France"
      ],
      "name": "Charlotte Cordonnier"
    },
    {
      "affiliations": [
        "Department of Neurology, CHRU Gui de Chauliac, Montpellier, France"
      ],
      "name": "Caroline Arquizan"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, CHRU Gui de Chauliac, Montpellier, France"
      ],
      "name": "Vincent Costalat"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Lariboisière Hospital, Paris, France"
      ],
      "name": "Alexis Guedon"
    },
    {
      "affiliations": [
        "Diagnostic and Therapeutic Neuroradiology, Hôpital Purpan, Toulouse, France"
      ],
      "name": "Christophe Cognard"
    },
    {
      "affiliations": [
        "Department of Statistics, APHP, Paris, France"
      ],
      "name": "Lakhdar Mameri"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France"
      ],
      "name": "Simon Escalard"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France"
      ],
      "name": "Hocine Redjem"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Stanislas Smajda"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Erwan Robichon"
    },
    {
      "affiliations": [
        "Fondation Adolphe de Rothschild, Paris, France"
      ],
      "name": "Amira Al Raaisi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "William Boisseau"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France"
      ],
      "name": "Raphaël Blanc"
    },
    {
      "affiliations": [
        "Department of Neurology, Hopital Saint Joseph, Paris, France"
      ],
      "name": "Benjamin Maier"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology Department, Biological Resource Center, Paris, France"
      ],
      "name": "Perrine Boursin"
    },
    {
      "affiliations": [
        "Department of Neurology, Hospital Lariboisière, Paris, France"
      ],
      "name": "Estelle Dubus"
    },
    {
      "affiliations": [
        "Department of Interventional neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"
      ],
      "name": "Jean-Philippe Desilles"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Michel Piotin"
    },
    {
      "affiliations": [
        "Université Paris Cité, Paris, France",
        "Department of Statistics, APHP, Paris, France"
      ],
      "name": "Matthieu Resche Rigon"
    },
    {
      "affiliations": [
        "Department of Neurology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Jean-Marc Olivot"
    }
  ],
  "title": "Glenzocimab for reperfusion in the setting of endovascular therapy for brain infarction: GREEN study",
  "uid": "b8b07566-f4c2-5714-92d3-87ec553dad00"
}