{
  "abstract": "Background Stent-assisted coiling is widely used for the treatment of wide-necked intracranial aneurysms. The pEGASUS-HPC stent features a hydrophilic polymer coating designed to reduce thrombogenicity, potentially improving safety, particularly in ruptured aneurysms and complex configurations.Objective To evaluate the safety, efficacy, and technical feasibility of stent-assisted coiling using the pEGASUS-HPC stent in the treatment of wide-necked intracranial aneurysms.Methods We retrospectively analyzed 223 patients with 251 wide-necked aneurysms treated at six centers between July 2021 and March 2025. Primary endpoints included angiographic occlusion (modified Raymond–Roy classification, MRRC), periprocedural complications, and clinical outcome (modified Rankin Scale, mRS) at discharge and follow-up. Subgroup analysis was performed for ruptured aneurysms and bifurcation cases requiring Y-stenting.Results Stent deployment and coiling were technically successful in all cases. Immediate complete occlusion (MRRC I) was achieved in 92.4% of aneurysms, increasing to 96.8% at follow-up. The overall retreatment rate was 2.2%. Periprocedural complications occurred in 1.6% of cases, consisting of two minor perforations in unruptured aneurysms, both managed without clinical consequences. In ruptured cases a favorable outcome (mRS ≤2) was observed in 71.1%, with mortality confined to Hunt and Hess grade V or basilar artery aneurysms. Y-stenting was performed in 15.9% of cases without technical failure. No perforations occurred in ruptured cases.Conclusion Stent-assisted coiling with the pEGASUS-HPC stent appears technically feasible and effective for wide-necked aneurysms, including acute ruptured cases and those requiring Y-stenting, with high occlusion rates and low complication rates.",
  "authors": [
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"
      ],
      "name": "Mohammad Almohammad"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany"
      ],
      "name": "Ali Khanafer"
    },
    {
      "affiliations": [
        "Department of Radiology, St Vincenz Hospital Paderborn, Paderborn, Germany"
      ],
      "name": "Mete Dadak"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neurosurgery, University Hospital of Giessen and Marburg Campus, Marburg, Germany"
      ],
      "name": "Christopher Nimsky"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neurosurgery, University Hospital of Giessen and Marburg Campus, Marburg, Germany"
      ],
      "name": "Alexander Grote"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"
      ],
      "name": "Bayan Alhaj Moustafa"
    },
    {
      "affiliations": [
        "Neurology, South Valley University, Qena, Qena Governorate, Egypt"
      ],
      "name": "Islam El Malky"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"
      ],
      "name": "Lisa Hekers"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"
      ],
      "name": "Abdallah Aburub"
    },
    {
      "affiliations": [
        "Central Institute for Diagnostic and Interventional Radiology Neuroradiology and Nuclear Medicine, Offenbach am Main, Germany"
      ],
      "name": "Zakarya Ali"
    },
    {
      "affiliations": [
        "Fachbereich Medizin, Philipps-Universität Marburg, Marburg, Germany",
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"
      ],
      "name": "Mariana Gurschi"
    },
    {
      "affiliations": [
        "Institute for Diagnostic and Interventional Radiology and Neuroradiology, Koblenz, Germany"
      ],
      "name": "Julia Korthäuer"
    },
    {
      "affiliations": [
        "Institute for Diagnostic and Interventional Radiology and Neuroradiology, Koblenz, Germany"
      ],
      "name": "Stephan Felber"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany",
        "Klinik für Neuroradiologie, Klinikum Stuttgart, Stuttgart, Germany"
      ],
      "name": "Hans Henkes"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany",
        "Department of Neuroradiology, Rhön Klinikum, Campus Bad Neustadt, Bad Neustadt an der Saale, Germany"
      ],
      "name": "André Kemmling"
    }
  ],
  "title": "Safety and efficacy of stent-assisted coiling with the pEGASUS-HPC stent in wide-necked intracranial aneurysms: a multicenter retrospective analysis",
  "uid": "535a7a45-1382-5f8b-b3b1-acf8e6bdeec4"
}