{
  "abstract": "Background The early prediction of functional outcomes in patients with posterior circulation stroke (PCS) is crucial for timely interventions and optimizing treatment plans. We have developed and validated a machine learning (ML) model for predicting 3-month functional outcomes in patients with PCS undergoing endovascular thrombectomy (EVT).Methods The derivation cohort, consisting of 202 patients with PCS who underwent EVT at four medical centers from January 2020 to December 2023, was separated for training and internal validation, and an external dataset of 54 patients admitted from January 2020 to July 2023 was used for external validation. The target outcome was a good functional outcome, defined as a modified Rankin Scale score of 0–3 at 3 months. Seven ML models were trained using preoperative features, with the primary evaluation metric being the area under the receiver operating characteristic curve (AUC). The top performing model was further trained using intraoperative and postoperative features. Model interpretations were generated using the Shapley additive explanations (SHAP) method.Results The Random Forest model demonstrated the best discriminative ability among the models considered. After feature selection, the final preoperative model used seven features, achieving an AUC of 0.83 in the test set and 0.81 in the external validation cohort. The inclusion of intraoperative and postoperative features further enhanced the model’s performance, resulting in an AUC of 0.84 and 0.90 in the test set and 0.83 and 0.90 in the external validation cohort, respectively. These models have been incorporated into a publicly accessible web-based calculator ( https://zhelvyao-123-60-basilarz.streamlit.app).Conclusion The interpretable ML models provide dynamic accurate predictions of functional outcomes in patients with PCS after EVT, offering valuable insights for personalized risk stratification and optimizing perioperative management, with potential for integration into clinical workflows.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Zhelv Yao"
    },
    {
      "affiliations": [
        "Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China"
      ],
      "name": "Qiuhong Ji"
    },
    {
      "affiliations": [
        "Department of Neurology, the First people's Hospital of Yancheng, Yancheng, China"
      ],
      "name": "Xuefeng Zang"
    },
    {
      "affiliations": [
        "Department of Neurology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China"
      ],
      "name": "Wenwei Yun"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Yun Luo"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, the First People's Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou, China"
      ],
      "name": "Jie Cao"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Jingxian Xu"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Zhihong Ke"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Ziyi Xie"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Chenglu Mao"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Qiaochu Guan"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Weiping Lv"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Zhengyang Zhu"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Yanan Huang"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, the First People's Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou, China"
      ],
      "name": "Ya Peng"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China",
        "Jiangsu Key Laboratory for Molecular Medicine and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China",
        "Nanjing Neurology Clinical Medical Center, and Nanjing Gulou Hospital Brain disease and Brain Science Center, Nanjing, China"
      ],
      "name": "Yun Xu"
    }
  ],
  "title": "Explainable machine learning model for predicting functional outcomes in posterior circulation stroke after thrombectomy",
  "uid": "badb098d-6f20-510c-811e-3845a279b59b"
}