{
  "abstract": "Background The impact of renal function on patients receiving endovascular thrombectomy (EVT) remains uncertain due to inconsistent results from previous studies. We investigated the effects of estimated glomerular filtration rate (eGFR) at admission on outcomes.Methods This cohort study analyzed data from the Taiwan Registry of EVT for Acute Ischemic Stroke (2019–24). Patients were categorized based on admission eGFR (mL/min/1.73 m²): renal hyperfiltration (≥120), normal renal function (60–119), mild renal impairment (30–59), moderate renal impairment (15–29), and end stage renal disease (ESRD <15).Results Among 2561 patients, the distribution was: 3.2% renal hyperfiltration, 69.6% normal renal function, 24.1% mild/moderate renal impairment, and 3.1% ESRD. Functional independence at 90 days declined with worsening renal function (43.2% to 11.3%), while mortality increased (18.5% to 43.8%). After multivariable adjustment, both renal hyperfiltration (adjusted OR (aOR) 0.35; 95% CI 0.18 to 0.67) and ESRD (aOR 0.35; 95% CI 0.15 to 0.78) were independently associated with reduced 90 day functional independence. Renal impairment was associated with increased 90 day mortality. The beneficial effect of successful recanalization on survival diminished in patients with renal impairment. Post-EVT intracerebral hemorrhage risk remained similar across all eGFR groups. These results were consistent across predefined subgroups.Conclusions Both renal hyperfiltration and impairment predicted worse outcomes after EVT, but did not increase the risk of hemorrhage. The results indicate that EVT remains appropriate for all eligible patients, regardless of renal function.",
  "authors": [
    {
      "affiliations": [
        "Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Hospital, Hsinchu, Taiwan",
        "Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan"
      ],
      "name": "Kuo-Wei Chen"
    },
    {
      "affiliations": [
        "Program in Medical Neuroscience, Taipei Medical University, Taipei City, Taiwan"
      ],
      "name": "Yi-Chen Hsieh"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan"
      ],
      "name": "Kun-Chang Tsai"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital, Taipei City, Taiwan"
      ],
      "name": "Chih-Hao Chen"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital, Taipei City, Taiwan"
      ],
      "name": "Sung-Chun Tang"
    },
    {
      "affiliations": [
        "Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan",
        "School of Medicine, National Yang-Ming University, Taipei, Taiwan"
      ],
      "name": "Chun-Jen Lin"
    },
    {
      "affiliations": [
        "Department of Neurology, Landseed International Medical Group, Taoyuan City, Taiwan"
      ],
      "name": "Yu-Wei Chen"
    },
    {
      "affiliations": [
        "Chi Mei Medical Center, Tainan, Taiwan"
      ],
      "name": "Kuan-Hung Lin"
    },
    {
      "affiliations": [
        "Neurology, National Cheng Kung University Hospital, Tainan, Taiwan"
      ],
      "name": "Pi-Shan Sung"
    },
    {
      "affiliations": [
        "Department of Neurology, Far Eastern Memorial Hospital, New Taipei City, Taiwan",
        "Institute of Brain Science, Brain Research Center, National Yang-Ming University, Taipei, Taiwan"
      ],
      "name": "Chih-Wei Tang"
    },
    {
      "affiliations": [
        "Neurology, En Chu Kong Hospital of the Hsing Tian Kong Foundation Medical Mission, New Taipei City, Taiwan"
      ],
      "name": "Hai-Jui Chu"
    },
    {
      "affiliations": [
        "Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan"
      ],
      "name": "Chao-Liang Chou"
    },
    {
      "affiliations": [
        "Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Lukang, Taiwan"
      ],
      "name": "Cheng-Yu Wei"
    },
    {
      "affiliations": [
        "Department of Neurology, Tri-Service General Hospital, Taipei City, Taiwan"
      ],
      "name": "Shang-Yih Yen"
    },
    {
      "affiliations": [
        "Department of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan"
      ],
      "name": "Po-Lin Chen"
    },
    {
      "affiliations": [
        "Shin Kong Wu Ho Su Memorial Hospital, Taipei City, Taiwan"
      ],
      "name": "Hsu-Ling Yeh"
    },
    {
      "affiliations": [
        "Neurology, Shuang Ho Hospital Department of Neurology, New Taipei, Taiwan",
        "School of Medicine, Taipei Medical University College of Medicine, Taipei City, Taiwan"
      ],
      "name": "Lung Chan"
    },
    {
      "affiliations": [
        "Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan, Taiwan"
      ],
      "name": "Sheng-Feng Sung"
    },
    {
      "affiliations": [
        "Medical Imaging, Fu Jen Catholic University College of Medicine, New Taipei, Taiwan"
      ],
      "name": "Hon-Man Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"
      ],
      "name": "Ching-Huang Lin"
    },
    {
      "affiliations": [
        "Neurology, Chang Gung Memorial Hospital Chiayi Branch, Puzi, Taiwan"
      ],
      "name": "Meng Lee"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Hospital, Hsinchu, Taiwan"
      ],
      "name": "Ya-Wen Jeng"
    },
    {
      "affiliations": [
        "Medical Imaging, National Taiwan University, Taipei City, Taiwan"
      ],
      "name": "Chung-Wei Lee"
    },
    {
      "affiliations": [
        "Department of Neurology, Taipei Veterans General Hospital, Taipei City, Taiwan"
      ],
      "name": "Chih-Ping Chung"
    },
    {
      "affiliations": [
        "Medical Imaging, Far Eastern Memorial Hospital, New Taipei, Taiwan"
      ],
      "name": "Yen-Jun Lai"
    },
    {
      "affiliations": [
        "Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan"
      ],
      "name": "Li-Ming Lien"
    },
    {
      "affiliations": [
        "Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan"
      ],
      "name": "Jiunn-Tay Lee"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan"
      ],
      "name": "Li-Kai Tsai"
    },
    {
      "affiliations": [
        "Neurology, Taipei Medical University, Taipei City, Taiwan"
      ],
      "name": "Hung-Yi Chiou"
    },
    {
      "affiliations": [
        "Neurology, National Taiwan University Hospital, Taipei City, Taiwan"
      ],
      "name": "Jiann-Shing Jeng"
    },
    {
      "affiliations": [],
      "name": "TREAT‐AIS (Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke) investigators"
    }
  ],
  "title": "Renal function and post-thrombectomy outcomes and safety: nationwide registry study",
  "uid": "b2b8a552-80a9-504f-a280-863bf3b34ad3"
}