{
  "abstract": "Background The Monopoint reperfusion system (Monopoint; Route 92 Medical, San Mateo, California, USA) is a large bore (0.088 or 0.070 inch inner diameter) aspiration thrombectomy platform designed to minimize ledge effect and improve neurovascular navigation and embolectomy. We aimed to describe a multicenter, real world experience of the safety and performance of the Monopoint system in first line aspiration thrombectomy for large vessel occlusions (LVOs), outside of the recently completed SUMMIT MAX (A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System) clinical trial.Methods Adults with acute anterior circulation LVO stroke between January 2019 and December 2024 consecutively treated with first line aspiration thrombectomy using the Monopoint at 10 centers were retrospectively reviewed. The primary outcome was first pass effect (FPE, modified Thrombolysis in Cerebral Infarction (mTICI) 2C/3 on first pass) and modified FPE (mFPE, mTICI 2B/2C/3 on first pass). The primary safety outcome was the rate of intraprocedural complications attributed to the Monopoint system.Results In 193 included patients, median age was 67 years (IQR 67–78), and 46.6% (90/193) were women. Successful delivery of the aspiration catheter to the clot site occurred in 96.2% (185/193) of patients. FPE was achieved in 57.5% (111/193) and mFPE was achieved in 68.4% (132/193) of patients. Of 10 (5.2%) total complications, most were vasospasm treated with intra-arterial verapamil (8/193, 4.1%); major complications included one dissection (1/193, 0.5%) and one perforation (1/193, 0.5%).Conclusion This multicenter study of the Monopoint reperfusion system for LVO thrombectomy outside of the SUMMIT MAX trial demonstrated a high FPE rate and a low rate of major complications.",
  "authors": [
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Manisha Koneru"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Jane Khalife"
    },
    {
      "affiliations": [
        "Department of Interventional Radiology, Oregon Health and Science University, Portland, Oregon, USA"
      ],
      "name": "Marco Colasurdo"
    },
    {
      "affiliations": [
        "Department of Interventional Radiology, Oregon Health and Science University, Portland, Oregon, USA"
      ],
      "name": "Ryan Priest"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Oregon Health and Science University, Portland, Oregon, USA"
      ],
      "name": "Matthew K McIntyre"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, Sutter California Pacific Medical Center, San Francisco, California, USA",
        "Department of Neurointerventional Surgery, Sutter Mills Peninsula Medical Center, Burlingame, California, USA"
      ],
      "name": "Fabio Settecase"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, Sutter California Pacific Medical Center, San Francisco, California, USA",
        "Department of Neurointerventional Surgery, Sutter Mills Peninsula Medical Center, Burlingame, California, USA"
      ],
      "name": "Joey English"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, Sutter California Pacific Medical Center, San Francisco, California, USA",
        "Department of Neurointerventional Surgery, Sutter Mills Peninsula Medical Center, Burlingame, California, USA"
      ],
      "name": "Warren Kim"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, Sutter California Pacific Medical Center, San Francisco, California, USA",
        "Department of Neurointerventional Surgery, Sutter Mills Peninsula Medical Center, Burlingame, California, USA"
      ],
      "name": "Blaise W Baxter"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, Sutter California Pacific Medical Center, San Francisco, California, USA",
        "Department of Neurointerventional Surgery, Sutter Mills Peninsula Medical Center, Burlingame, California, USA"
      ],
      "name": "JaeHyun Kim"
    },
    {
      "affiliations": [
        "Department of Radiology, Boston Medical Center, Boston, Massachusetts, USA"
      ],
      "name": "Mohamad Abdalkader"
    },
    {
      "affiliations": [
        "Boston University School of Medicine, Boston, Massachusetts, USA"
      ],
      "name": "Piers Klein"
    },
    {
      "affiliations": [
        "Department of Neurology, Boston Medical Center, Boston, Massachusetts, USA"
      ],
      "name": "Thanh N Nguyen"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Radiology, Sutter Health Sacramento Medical Center, Sacramento, California, USA"
      ],
      "name": "Matthew D Alexander"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania, USA"
      ],
      "name": "Oded Goren"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania, USA"
      ],
      "name": "Philipp Hendrix"
    },
    {
      "affiliations": [
        "Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA"
      ],
      "name": "Tyler Bielinski"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ohio Health Riverside Methodist Hospital, Columbus, Ohio, USA"
      ],
      "name": "Peter J Pema"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Chicago, Chicago, Illinois, USA"
      ],
      "name": "Rami Z Morsi"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Chicago, Chicago, Illinois, USA"
      ],
      "name": "Tareq Kass-Hout"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Pratit Patel"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Ajith J Thomas"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Tudor G Jovin"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Hamza A Shaikh"
    },
    {
      "affiliations": [
        "Cooper Neurological Institute, Cooper University Health Care, Camden, New Jersey, USA",
        "Cooper Medical School of Rowan University, Camden, New Jersey, USA"
      ],
      "name": "Daniel A Tonetti"
    }
  ],
  "title": "Multicenter experience of the Monopoint reperfusion system in acute large vessel occlusion stroke thrombectomy",
  "uid": "fa785b29-b4a5-514d-9dd3-4aef3a631f2c"
}