{
  "abstract": "Background The presence of a coincident intracranial aneurysm (CIA) on the target vessel of patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke (AIS) poses challenges, as the benefits and risks of the procedure in this scenario remain unclear. This study aimed to evaluate the efficacy and safety of MT in AIS cases with a CIA on the target vessel.Methods We retrospectively analyzed data from 14 stroke centers in France and Switzerland between January 2015 and January 2023. We identified AIS cases with CIA on the target vessel treated with MT. The control population was constituted from the ETIS registry (Endovascular Treatment in Ischemic Stroke), including AIS patients treated with MT in the same centers during the same period, and were matched (1:4) on age (±1 year) and sex. The primary outcome was favorable functional status at 3 months, defined as a modified Rankin Scale (mRS) score ≤2 or equal to pre-stroke mRS.Results A total of 104 MT-treated patients with at least one CIA on the target vessel and 416 MT-treated patients without CIA were analyzed. Despite an aneurysm rupture occurring in 5.8% of cases, no significant differences were observed in favorable functional outcome at 3 months between the CIA and control groups (42.4% vs 41.0%; adjusted OR 1.20, 95% CI 0.72 to 1.97). Similarly, recanalization rates (modified Thrombolysis In Cerebral Infarction (mTICI) ≥2b at end of MT) did not differ significantly (90.0% vs 85.9%; adjusted OR 1.75, 95% CI 0.77 to 3.95).Conclusion MT is an effective option for AIS patients, even with CIA on the target vessel, but the risk of rupture underscores the need for procedural planning. Future studies should further explore size and location criteria to optimize patient selection and orientation.",
  "authors": [
    {
      "affiliations": [
        "Radiology, CHU Poitiers Pôle imagerie diagnostique fonctionnelle et thérapeutique, Poitiers, France"
      ],
      "name": "Melina Combeau"
    },
    {
      "affiliations": [
        "Department of Biostatistics, Lille University Hospital, Lille, Hauts-de-France, France"
      ],
      "name": "Julien Labreuche"
    },
    {
      "affiliations": [
        "UMR CNRS 7348, Poitiers, Nouvelle-Aquitaine, France"
      ],
      "name": "Clément Louis Giraud"
    },
    {
      "affiliations": [
        "Neuroradiology, Marseille Public University Hospital System, Marseille, Provence-Alpes-Côte d’Azu, France"
      ],
      "name": "Thibault Agripnidis"
    },
    {
      "affiliations": [
        "neuroradiology, APHM, Marseille, Provence-Alpes-Côte d’Azu, France"
      ],
      "name": "Jean-Francois Hak"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology department, Strasbourg University Hospitals, Strasbourg, Grand Est, France"
      ],
      "name": "Ian Leonard-Lorant"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, University Hospitals Strasbourg, Strasbourg, France",
        "Interventional Radiology, Institut de Chirurgie Guidée par l’Image, Strasbourg, France"
      ],
      "name": "Raoul Pop"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Pitié-Salpêtrière University Hospital, Paris, Île-de-France, France"
      ],
      "name": "Julien Allard"
    },
    {
      "affiliations": [
        "Sorbonne University, Paris, Île-de-France, France",
        "Neuroradiology, Pitié-Salpêtrière University Hospital, Paris, Île-de-France, France"
      ],
      "name": "Frédéric Clarençon"
    },
    {
      "affiliations": [
        "Lariboisière Hospital Neuroradiology Service, Paris, Île-de-France, France"
      ],
      "name": "Alexis Guedon"
    },
    {
      "affiliations": [
        "Radiology, University Hospital Centre Rouen Division of Medical Imaging, Rouen, Normandy, France"
      ],
      "name": "Julien Burel"
    },
    {
      "affiliations": [
        "Radiology, University Hospital Centre Rouen Division of Medical Imaging, Rouen, Normandy, France"
      ],
      "name": "Margaux Lefebvre"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology, CHU Tours, Tours, Centre, France"
      ],
      "name": "Heloise Ifergan"
    },
    {
      "affiliations": [
        "Neuroradiology, Regional University Hospital Centre Tours Radiology Diagnostic and Interventional Neuroradiology, Tours, Centre-Val de Loire, France"
      ],
      "name": "Gregoire Boulouis"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Centre Clermont-Ferrand Division of Diagnostic Imaging and Interventional Radiology, Clermont-Ferrand, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Géraud Forestier"
    },
    {
      "affiliations": [
        "Neuroradiology, CHRU de Nancy, Nancy, France",
        "Instituto Oulton, Cordoba, Argentina"
      ],
      "name": "Patricio Muszynski"
    },
    {
      "affiliations": [
        "Diagnostic and Therapeutic Neuroradiology, Nancy Regional University Hospital Center, Nancy, Grand Est, France",
        "Laboratoire IADI INSERM-U1254, Vandœuvre-lès-Nancy, Grand Est, France"
      ],
      "name": "François Zhu"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology, Hôpitaux Civils de Colmar, Colmar, Alsace, France"
      ],
      "name": "Federico Bolognini"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology, Hôpitaux Civils de Colmar, Colmar, Alsace, France"
      ],
      "name": "Pablo Ariel Lebedinsky"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital Basel, Basel, Switzerland"
      ],
      "name": "Peter B Sporns"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Centre Reims Medical Imaging, Reims, France",
        "INSERM UMR-S U1237, Université de Caen Normandie, Caen, France"
      ],
      "name": "Sebastien Soize"
    },
    {
      "affiliations": [
        "Neurology, Hôpital Jean Minjoz, Besancon, France"
      ],
      "name": "Guillaume Charbonnier"
    },
    {
      "affiliations": [
        "Radiology, CHU Poitiers Pôle imagerie diagnostique fonctionnelle et thérapeutique, Poitiers, France",
        "UMR CNRS 7348, Poitiers, Nouvelle-Aquitaine, France"
      ],
      "name": "Rémy Guillevin"
    },
    {
      "affiliations": [
        "Radiology, CHU Poitiers Pôle imagerie diagnostique fonctionnelle et thérapeutique, Poitiers, Nouvelle-Aquitaine, France"
      ],
      "name": "Stéphane Velasco"
    },
    {
      "affiliations": [
        "Hospital Foch, Suresnes, Île-de-France, France"
      ],
      "name": "Bertrand Lapergue"
    },
    {
      "affiliations": [
        "Radiology, CHU Poitiers Pôle imagerie diagnostique fonctionnelle et thérapeutique, Poitiers, France",
        "UMR CNRS 7348, Poitiers, Nouvelle-Aquitaine, France"
      ],
      "name": "Victor Dumas"
    },
    {
      "affiliations": [],
      "name": "Endovascular Treatment in Ischemic Stroke (ETIS) centers"
    }
  ],
  "title": "Coincident intracranial aneurysm on the target vessel of acute ischemic stroke treated with mechanical thrombectomy: a multicentric case-control study",
  "uid": "d3249018-2ec0-5ce2-a65a-31a1acc04acc"
}