{
  "abstract": "Background The present study reports a multicenter experience of using hydrophilic polymer-coated (HPC) flow diverters (FDs) with prasugrel single antiplatelet therapy (SAPT) to treat posterior circulation aneurysms (PCAs).Methods A prospectively maintained database was retrospectively reviewed to identify all cases of intracranial PCA treated with HPC-coated FDs under SAPT (prasugrel). The clinical presentation and outcomes, periprocedural and postprocedural complications, and degree of occlusion at follow-up (FU) were evaluated.Results A total of 74 patients were treated (45.9% female). Ischemic complications were experienced by two patients (2.7%) and were dependent on the use of FDs. No cases of aneurysm rupture or hemorrhagic complications related to antiplatelet therapy or the FD treatment were recorded. The rate of complete occlusion was 77.9% in the early FU period (3–6 months) and 90.3% in the initial 12-month period.Conclusion In this single-arm retrospective study, HPC-coated FDs with prasugrel SAPT were associated with high safety in the treatment of ruptured and unruptured PCA and high occlusion rates at early- and mid-term FU.",
  "authors": [
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany"
      ],
      "name": "Ali Khanafer"
    },
    {
      "affiliations": [
        "Radiology Department, UH St Ivan Rilski, Sofia, Bulgaria"
      ],
      "name": "Alexander Sirakov"
    },
    {
      "affiliations": [
        "Institute of Diagnostic and Interventional Radiology and Neuroradiology, HELIOS Klinikum Erfurt, Erfurt, Germany"
      ],
      "name": "Donald Lobsien"
    },
    {
      "affiliations": [
        "Neurosurgery & Radiology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel"
      ],
      "name": "José E Cohen"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Marburg, Marburg, Germany, Marburg, Germany"
      ],
      "name": "Mohammad almohammad"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Halle, Halle, Germany"
      ],
      "name": "Marie-Sophie Schüngel"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany"
      ],
      "name": "Florian Hennersdorf"
    },
    {
      "affiliations": [
        "Neuroradiology, Bahrmherzige Bruder Krankenhaus Regensburg, Regensburg, Germany"
      ],
      "name": "Thomas Borgmann"
    },
    {
      "affiliations": [
        "Central Institute for Diagnostic and Interventional Radiology Neuroradiology and Nuclear Medicine, Central Institute for Diagnostic and Interventional Radiology Neuroradiology and Nuclear Medicine, Offenbach am Main, Germany"
      ],
      "name": "Zakarya Ali"
    },
    {
      "affiliations": [
        "Neurology, Department of Neurosurgery, Institute of Emergency Care, Chisinau, Moldova (the Republic of)"
      ],
      "name": "Andrei Filioglo"
    },
    {
      "affiliations": [
        "Klinik für Neurologie, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany, Stuttgart, Germany"
      ],
      "name": "Hansjörg Bäzner"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany"
      ],
      "name": "Philipp von Gottberg"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany"
      ],
      "name": "Kamran Hajiyev"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany"
      ],
      "name": "Pablo Albiña-Palmarola"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Radiology Neuroradiology, Gemeinschaftsklinikum Koblenz Mayen, Koblenz, Germany, Koblenz, Germany"
      ],
      "name": "Stephan Felber"
    },
    {
      "affiliations": [
        "Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany"
      ],
      "name": "Michael Forsting"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Halle, Halle, Germany"
      ],
      "name": "Stefan Schob"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Marburg, Marburg, Germany, Marburg, Germany"
      ],
      "name": "André Kemmling"
    },
    {
      "affiliations": [
        "Institute of Diagnostic and Interventional Radiology and Neuroradiology, HELIOS Klinikum Erfurt, Erfurt, Germany"
      ],
      "name": "Joachim Klisch"
    },
    {
      "affiliations": [
        "Radiology Department, UH St Ivan Rilski, Sofia, Bulgaria"
      ],
      "name": "Stanimir Sirakov"
    },
    {
      "affiliations": [
        "Neuroradiology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany",
        "Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany"
      ],
      "name": "Hans Henkes"
    }
  ],
  "title": "Endovascular treatment of posterior circulation aneurysms with flow diverters with hydrophilic polymer coating in patients receiving prasugrel single antiplatelet therapy: a multicenter case series presenting complication and occlusion rates",
  "uid": "b2e76ce6-441e-5eaf-a449-c075ea5c189a"
}