{
  "abstract": "Background Contrast-induced encephalopathy (CIE) is an increasingly observed complication following neurointervention, but remains poorly defined with limited evidence for clinical decision-making. We sought to characterize the stereotypical clinical features of CIE in a nationwide, multicenter cohort.Methods A multicenter cohort study was conducted between 10 neurovascular sites across Australia. Patients were screened according to the previously proposed Australian diagnostic criteria. Descriptive analysis was conducted to characterize the clinical course and outcomes of CIE, and associations between clinical and radiological variables on patient outcomes were analyzed using Fisher’s exact and χ 2 tests.Results A total of 56 patients (median age 65 years) were included. The median contrast volume was 170 mL (IQR 140–229). Median time to symptom onset was 6 hours (IQR 1–12), with frequent symptoms including motor deficit (55.4%), dysphasia (39.3%), and confusion (35.7%). Common radiological findings included sulcal effacement (45.5%) and subarachnoid contrast staining (30.9%) on CT. Hemianopia (p=0.001) and cortical blindness (p=0.018) were associated with posterior circulation interventions, while motor deficit was correlated with anterior circulation interventions (p=0.001). At discharge, 87.5% of patients achieved complete resolution of symptoms, of which 69.4% achieved complete recovery within 72 hours.Conclusion CIE is a recognized complication of neurointervention. Symptoms occur within hours of contrast administration and correlate with the territory of contrast administration. Most patients achieve complete symptom resolution. Ongoing investigation is required to further define CIE as a clinical entity.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia",
        "Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Frederick P Mariajoseph"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia",
        "Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Leon T Lai"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia",
        "Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Adrian Praeger"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia",
        "Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Justin Moore"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia",
        "Department of Radiology, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Ronil V Chandra"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia",
        "Department of Interventional Neuroadiology, Austin Health, Melbourne, Victoria, Australia",
        "Department of Interventional Neuroradiology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Hamed Asadi"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Gold Coast University Hospital, Gold Coast, Queensland, Australia"
      ],
      "name": "Peter Fawzy"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Gold Coast University Hospital, Gold Coast, Queensland, Australia"
      ],
      "name": "Laetitia de Villiers"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia",
        "Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Tony Goldschlager"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Calvin Gan"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Kevin Zhou"
    },
    {
      "affiliations": [
        "Neurological Intervention & Imaging Service of WA [NIISwa] | SCGH, RPH & FSH, Western Australia Department of Health, Nedlands, Western Australia, Australia",
        "Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia"
      ],
      "name": "Albert Ho Yuen Chiu"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Boaz Kim"
    },
    {
      "affiliations": [
        "Department of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia",
        "School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia"
      ],
      "name": "Ferdi Miteff"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Royal Hobart Hospital, Hobart, Tasmania, Australia"
      ],
      "name": "Ramon Martin Francisco Bañez"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroadiology, Austin Health, Melbourne, Victoria, Australia",
        "Department of Interventional Neuroradiology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Davor Pavlin-Premrl"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia",
        "Department of Radiology, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Department of Interventional Neuroradiology, Alfred Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Winston Chong"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Royal Brisbane and Woman’s Hospital Health Service District, Herston, Queensland, Australia"
      ],
      "name": "Robert Fang"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Royal Brisbane and Woman’s Hospital Health Service District, Herston, Queensland, Australia"
      ],
      "name": "Kate Mahady"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Royal Brisbane and Woman’s Hospital Health Service District, Herston, Queensland, Australia"
      ],
      "name": "Sophie Dunkerton"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Royal North Shore Hospital, St Leonards, New South Wales, Australia"
      ],
      "name": "Brendan Steinfort"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Alfred Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Bjoern Picker"
    },
    {
      "affiliations": [
        "Monash Imaging, Monash Health, Clayton, Victoria, Australia",
        "Department of Radiology, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Lee-Anne Slater"
    }
  ],
  "title": "Nationwide multicenter experience of contrast-induced encephalopathy following neurointervention: clinical course and outcomes",
  "uid": "aca30f82-90d0-59fa-b006-28c628b18812"
}