{
  "abstract": "Background A critical evaluation of the US Food and Drug Administration (FDA) recommendation to avoid intracranial stent placement (ICAS) within 7 days of a qualifying cerebral ischemic event.Methods This evaluation compared the rates of 1 month stroke and/or death associated with ICAS performed within 7 days and more than 7 days after a qualifying cerebral ischemic event in patients with high-grade (70–99% in severity) intracranial stenosis in two randomized controlled trials. A logistic regression analysis was performed to identify the impact of time interval strata between the qualifying cerebral ischemic event and ICAS on 1 month stroke and/or death rate (independent ascertainment).Results The rates of 1 month stroke and/or death were 14 of 112 (12.5%) and 33 of 172 (19.2%) in patients treated within 7 days and more than 7 days after a qualifying cerebral ischemic event, respectively (P=0.071). There was no difference in the 1 month stroke and/or death rate in patients who were treated within 7 days and those treated after 7 days after a qualifying cerebral ischemic event (OR 1.0004, 95% CI 0.55 to 1.84) after adjusting for age, gender, severity of stenosis strata, qualifying cerebral ischemic event type (transient ischemic attack or minor ischemic stroke), and stent used (self-expanding vs balloon expandable stents).Conclusions This analysis did not show any increased risk of 1 month stroke and/or death in patients who underwent ICAS within 7 days compared with those treated more than 7 days after the qualifying cerebral ischemic event. Delaying the ICAS according to current FDA recommendations may not be necessary when ICAS is indicated.",
  "authors": [
    {
      "affiliations": [
        "Zeenat Qureshi Stroke Institute, Columbia, Missouri, USA",
        "Department of Neurology, University of Missouri, Columbia, Missouri, USA"
      ],
      "name": "Adnan I Qureshi"
    },
    {
      "affiliations": [
        "Department of Statistics, University of Missouri, Columbia, Missouri, USA"
      ],
      "name": "Yilun Huang"
    },
    {
      "affiliations": [
        "Department of Neuroscience, Valley Baptist Health System Inc, Harlingen, Texas, USA"
      ],
      "name": "Ameer E Hassan"
    },
    {
      "affiliations": [
        "Zeenat Qureshi Stroke Institute, Columbia, Missouri, USA",
        "Department of Neurology, University of Missouri, Columbia, Missouri, USA"
      ],
      "name": "Nived Jayaraj Ranjini"
    },
    {
      "affiliations": [
        "Zeenat Qureshi Stroke Institute, Columbia, Missouri, USA"
      ],
      "name": "M Fareed K Suri"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Missouri, Columbia, Missouri, USA"
      ],
      "name": "Camilo R Gomez"
    }
  ],
  "title": "Timing of intracranial stent placement and one month stroke and/or death rates in patients with high-grade symptomatic intracranial stenosis: pooled analysis of SAMMPRIS and VISSIT trials",
  "uid": "671998ae-a939-5370-b8f0-afe9c92d60e7"
}