{
  "abstract": "Background The endovascular clip system (eCLIPs), a unique extra-saccular device for treatment of wide necked bifurcation aneurysms (WNBAs), was evaluated in the French eCLIPs efficacy and safety study (EESIS-FR). This paper summarizes the patient demographics, procedural characteristics, and 30 day adverse event (AE) data.Methods The EESIS-FR trial was a prospective study from 18 centers, enrolling 123 adults with WNBAs at the carotid (CT) and basilar (BT) termini. The study protocol was approved by a central ethics committee, had independent adjudication of AEs by a Clinical Events Committee, and had independent core laboratory adjudication of effectiveness outcomes.Results Mean age was 55.0±1.2 years (19–78 years); 73% were women. 43% and 57% of the aneurysms were located at BT and CT, respectively. Mean neck length was 4.8 mm, neck depth 4.2 mm, dome height 5.4 mm, and dome width 6.3 mm. Successful implantation was achieved in 115 cases (93%). Implant time averaged 36 min. Three primary safety events (2.4%) occurred within the first 30 days, all at the index procedure: subarachnoid hemorrhage (SAH) due to a distal guidewire perforation, death from SAH due to rupture of the aneurysm, and spinal cord infarction caused by an occlusive access catheter. Five minor strokes (4.1%) and three transient ischemic attacks (2.4%) occurred, all of which were procedurals. None of these patients had a modified Rankin Scale score of >2 at 30 days. No patient had further ischemic or hemorrhagic events beyond the periprocedural period to 30 days.Conclusion eCLIPs treated WNBAs at BT and CT, with procedural safety and technical success similar to those with intrasaccular devices.",
  "authors": [
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Raphaël Blanc"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Lyon, France"
      ],
      "name": "Roberto Riva"
    },
    {
      "affiliations": [
        "Neuroradiologie, Hôpital Privé Clairval, Marseille, France"
      ],
      "name": "Olivier Levrier"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, CHU de Rouen, Rouen, France"
      ],
      "name": "Chrisanthi Papagiannaki"
    },
    {
      "affiliations": [
        "Neuroradiologie Interventionnelle, Hopital Sainte Anne, Université Paris Descartes Faculté de Médecine, Paris, France"
      ],
      "name": "Olivier Naggara"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Hocine Redjem"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, NEURI, Kremlin-Bicêtre, France"
      ],
      "name": "Laurent Spelle"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France"
      ],
      "name": "Benjamin Gory"
    },
    {
      "affiliations": [
        "Neuroradiologie, CHU Nantes, Nantes, France"
      ],
      "name": "Hubert Desal"
    },
    {
      "affiliations": [
        "Hôpital d’Instruction des Armées Sainte-Anne, Toulon, France"
      ],
      "name": "Sebastien Gazzolla"
    },
    {
      "affiliations": [
        "Hôpital d’Instruction des Armées Sainte-Anne, Toulon, France"
      ],
      "name": "Quentin Holay"
    },
    {
      "affiliations": [
        "Neurointerventionnel, CHU Nice, Nice, France"
      ],
      "name": "Yves Chau"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Clinique des Cèdres, Cornebarrieu, France"
      ],
      "name": "Pierre Guedin"
    },
    {
      "affiliations": [
        "Neuroradiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France"
      ],
      "name": "Emmanuel Chabert"
    },
    {
      "affiliations": [
        "Neuroradiology, APHM, Marseille, France"
      ],
      "name": "Anthony Reyre"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, CHU Limoges, Limoges, France"
      ],
      "name": "Charbel Mounayer"
    },
    {
      "affiliations": [
        "CHU Rennes Service de radiologie et d’imagerie Médicale, Rennes, France"
      ],
      "name": "Quentin Alias"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital of Tours, Tours, France"
      ],
      "name": "Gregoire Boulouis"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, University Hospital Pitié Salpêtrière, Paris, France"
      ],
      "name": "Frédéric Clarençon"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, University Hospital Pitié Salpêtrière, Paris, France"
      ],
      "name": "Kevin Premat"
    },
    {
      "affiliations": [
        "Neuroradiology, Henri Mondor Hospital, Créteil, France"
      ],
      "name": "Erwah Kalsoum"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Simon Escalard"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "William Boisseau"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, CHU Grenoble, Grenoble, France"
      ],
      "name": "K Boubagra"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital of Tours, Tours, France"
      ],
      "name": "Kevin Janot"
    },
    {
      "affiliations": [
        "Neuroradiologie Interventionnelle, Hopital Sainte Anne, Université Paris Descartes Faculté de Médecine, Paris, France"
      ],
      "name": "Wagih Benhassen"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France"
      ],
      "name": "François Zhu"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France"
      ],
      "name": "Anne Laure Derelle"
    },
    {
      "affiliations": [
        "Neurointerventionnel, CHU Nice, Nice, France"
      ],
      "name": "Jacques Sédat"
    },
    {
      "affiliations": [
        "Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK"
      ],
      "name": "Phil White"
    },
    {
      "affiliations": [
        "Division of Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland"
      ],
      "name": "Paolo Machi"
    },
    {
      "affiliations": [
        "Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada"
      ],
      "name": "Robert Fahed"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France",
        "Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Lyon, France",
        "Neuroradiologie, Hôpital Privé Clairval, Marseille, France",
        "Interventional Neuroradiology, CHU de Rouen, Rouen, France",
        "Neuroradiologie Interventionnelle, Hopital Sainte Anne, Université Paris Descartes Faculté de Médecine, Paris, France",
        "Interventional Neuroradiology, NEURI, Kremlin-Bicêtre, France",
        "Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France",
        "Neuroradiologie, CHU Nantes, Nantes, France",
        "Hôpital d’Instruction des Armées Sainte-Anne, Toulon, France",
        "Neurointerventionnel, CHU Nice, Nice, France",
        "Interventional Neuroradiology, Clinique des Cèdres, Cornebarrieu, France",
        "Neuroradiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France",
        "Neuroradiology, APHM, Marseille, France",
        "Interventional Neuroradiology, CHU Limoges, Limoges, France",
        "CHU Rennes Service de radiologie et d’imagerie Médicale, Rennes, France",
        "Department of Neuroradiology, University Hospital of Tours, Tours, France",
        "Interventional Neuroradiology, University Hospital Pitié Salpêtrière, Paris, France",
        "Neuroradiology, Henri Mondor Hospital, Créteil, France",
        "Interventional Neuroradiology, CHU Grenoble, Grenoble, France",
        "Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK",
        "Division of Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland",
        "Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada",
        "Interventional neuroradiology Department Foundation Rothschild Hospital, Paris, France"
      ],
      "name": "EESIS-FR Collaborating Group"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Amira Al Raaisi"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France"
      ],
      "name": "Michel Piotin"
    }
  ],
  "title": "eCLIPs, a dedicated neck bridging device for wide neck bifurcation aneurysms: procedural and 30 day safety results of the French prospective trial",
  "uid": "be39251d-1ce0-5d37-90be-4b436baf2e90"
}