{
  "abstract": "Purpose Large bore catheters are increasingly used in mechanical thrombectomy (MT) for large vessel occlusions (LVOs).Objective To evaluate the efficacy and safety of the super-large bore Cereglide 0.092\" (C-92) catheter, featuring the largest inner diameter available.Methods A multicenter observational study was conducted across 12 comprehensive stroke centers in the United States. Efficacy outcomes included the first pass effect (FPE) and successful reperfusion. FPE was defined as a first MT pass achieving a modified Treatment in Cerebral Infarction (mTICI) score of ≥2c. Successful reperfusion was defined as final mTICI score ≥2c. Safety outcomes involved device-related complications, symptomatic intracranial hemorrhage (sICH), and inpatient mortality. Functional outcomes included modified Rankin Scale (mRS) score at discharge and delta National Institutes of Health Stroke Scale (NIHSS) score.Results Fifty patients were included. The most common LVO was the first segment of the middle cerebral artery in 31/50 cases (62%). The C-92 reached the thrombus in 41 patients (82%). Median puncture-to-thrombus and puncture-to-reperfusion times were 15 min (IQR 10–25) and 26 min (IQR 15–49), respectively. FPE was achieved in 25/50 (50%) cases, and in 25/41 (61%) cases when the C-92 reached the thrombus. Successful reperfusion occurred in 36/41 patients (88%). There were no vessel perforations, or sICH. Distal embolization occurred in 4/50 (8%) cases, and 4/50 (8%) died. The mRS score at discharge was 3 (IQR 2–6), and the delta NIHSS score was 8 (IQR 5–12).Conclusion The C-92 catheter demonstrated a safe profile achieving an overall FPE rate of 50%, and favorable functional outcomes in 88% of cases.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Neurosurgery and Radiology, University of Iowa, Iowa City, Iowa, USA"
      ],
      "name": "Edgar A Samaniego"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Andres Gudino"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Leonardo Cruz-Criollo"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Carlos Dier"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, JFK Health System, Edison, New Jersey, USA"
      ],
      "name": "Brian T Jankowitz"
    },
    {
      "affiliations": [
        "Department of Neurology, JFK Health System, Edison, New Jersey, USA"
      ],
      "name": "Aishwarya Aggarwal"
    },
    {
      "affiliations": [
        "Department of Neurology, JFK Health System, Edison, New Jersey, USA"
      ],
      "name": "Haralabos Zacharatos"
    },
    {
      "affiliations": [
        "Department of Neurology, UPMC Stroke Institute, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Alhamza R Al-Bayati"
    },
    {
      "affiliations": [
        "Department of Neurology, UPMC Stroke Institute, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Raul Nogueira"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Mohamed F Doheim"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Shahram Majidi"
    },
    {
      "affiliations": [
        "Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"
      ],
      "name": "Michael T Froehler"
    },
    {
      "affiliations": [
        "Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"
      ],
      "name": "Mir Amaan Ali"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Utah Health, Salt Lake City, Utah, USA"
      ],
      "name": "Ramesh Grandhi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Utah Health, Salt Lake City, Utah, USA"
      ],
      "name": "Santiago Gomez-Paz"
    },
    {
      "affiliations": [
        "Department of Neurology, Emory University, Atlanta, Georgia, USA"
      ],
      "name": "Jaydevsinh Dolia"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Radiology, Emory University School of Medicine, Atlanta, Georgia, USA"
      ],
      "name": "Jonathan A Grossberg"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Vinay Jaikumar"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Adnan Siddiqui"
    },
    {
      "affiliations": [
        "Department of Radiology, University of Massachusetts System, Boston, Massachusetts, USA"
      ],
      "name": "Ajit S Puri"
    },
    {
      "affiliations": [
        "Department of Radiology, University of Massachusetts System, Boston, Massachusetts, USA"
      ],
      "name": "Raymond Catton"
    },
    {
      "affiliations": [
        "Department of Radiology, University of Massachusetts System, Boston, Massachusetts, USA"
      ],
      "name": "Jasmeet Singh"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, West Virginia University, Morgantown, West Virginia, USA"
      ],
      "name": "Sohyun Boo"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, College of Medicine, University of Houston, Houston, Texas, USA",
        "Department of Neuroendovascular Surgery, HCA Houston, Houston, Texas, USA"
      ],
      "name": "Mohamad Ezzeldin"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Santiago Ortega-Gutierrez"
    },
    {
      "affiliations": [
        "Department of Neurology and Neurosurgery, Westchester Medical Center, Valhalla, New York, USA"
      ],
      "name": "Fawaz Al-Mufti"
    }
  ],
  "title": "Super-large bore catheter in the treatment of large vessel occlusions: initial multicenter experience",
  "uid": "6fd0c3a3-599d-5ca8-b08a-2da2ea7d6d27"
}