{
  "abstract": "Background The Woven EndoBridge (WEB) device is a prevalent treatment for intracranial aneurysms. While many studies have assessed the obliteration rate post-WEB embolization, few have focused on long-term outcomes in partially thrombosed aneurysms.Objective To assess whether partially thrombosed aneurysms are at higher risk of recurrence or retreatment following WEB embolization compared with non-thrombosed aneurysms.Methods We evaluated data from 22 academic institutions, focusing on previously untreated cerebral aneurysms treated with the WEB device. Logistic regression was utilized to analyze factors predicting long-term aneurysm obliteration and retreatment necessity.Results Among 1303 patients, 26 presented with a partially thrombosed aneurysm. In the partially thrombosed group, the mean aneurysm maximal diameter was 10.7±4 mm with a neck ratio of 1.99±1.19 mm, larger than in the control group where the mean aneurysm maximal diameter was 6.81±2.37 mm with a neck ratio of 1.64±0.51 mm (P<0.001 for both maximal diameter and neck ratio). At the final follow-up, partially thrombosed aneurysms treated by the WEB device had a 38.5% retreatment rate, compared with 7.0% for non-thrombosed aneurysms (P<0.001). Among partially thrombosed aneurysms, the Raymond-Roy type IIIa/b occlusion rate was higher (38.5% vs 9.9%, P<0.001). On multivariate analysis, partially thrombosed aneurysms compared with non-thrombosed aneurysms had an increased rate of retreatment (OR 3.64, 95% CI 1.28 to 10.1).Conclusion Partially thrombosed aneurysms are associated with a poorer occlusion rate and a higher rate of retreatment following WEB embolization. For partially thrombosed aneurysms, the WEB device appears suboptimal as a first-line treatment, and therefore alternative techniques should be prioritized.",
  "authors": [
    {
      "affiliations": [
        "Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland"
      ],
      "name": "Guillaume Saliou"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts, USA"
      ],
      "name": "Hamza Adel Salim"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Basel Musmar"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Nimer Adeeb"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University System, Shreveport, Louisiana, USA"
      ],
      "name": "Assala Aslan"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Christian Swaid"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Miguel Cuellar"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Mahmoud Dibas"
    },
    {
      "affiliations": [
        "Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael’s Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Nicole M Cancelliere"
    },
    {
      "affiliations": [
        "Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael’s Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Jose Danilo Bengzon Diestro"
    },
    {
      "affiliations": [
        "Department of Radiology, Ankara University Medical Faculty Ibn i Sina Hospital, Ankara, Turkey"
      ],
      "name": "Oktay Algin"
    },
    {
      "affiliations": [
        "Departments of Radiology and Neurosurgery, Mayo Clinic, Rochester, New York, USA"
      ],
      "name": "Sherief Ghozy"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"
      ],
      "name": "Sovann V Lay"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Hôpital Universitaire Erasme, Brussels, Belgium"
      ],
      "name": "Adrien Guenego"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ospedale Careggi Di Firenze, Firenze, Italy"
      ],
      "name": "Leonardo Renieri"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Neuroradiology, New York Presbyterian Hospital and Weill Cornell School of Medicine, New York, New York, USA"
      ],
      "name": "Joseph Anthony Carnevale"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Panagiotis Mastorakos"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Kareem ElNaamani"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Hôpital de la Pitié-Salpêtrière, Paris, France"
      ],
      "name": "Eimad Shotar"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, UniversitätsKlinikum Heidelberg, Heidelberg, Germany"
      ],
      "name": "Markus A Möhlenbruch"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Christian Doppler University Hospital & Institute of Neurointervention, Salzburg, Austria"
      ],
      "name": "Michael Kral"
    },
    {
      "affiliations": [
        "Departments of Radiology & Neurosurgery, NYU Langone Health, New York, New York, USA"
      ],
      "name": "Charlotte Chung"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Mohamed M Salem"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina"
      ],
      "name": "Ivan Lylyk"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Orlando Health Neuroscience and Rehabilitation Institute, Orlando, Florida, USA"
      ],
      "name": "Paul M Foreman"
    },
    {
      "affiliations": [
        "Department of Radiology & Neurosurgery, Cooper University Hospital, Camden, New Jersey, USA"
      ],
      "name": "Hamza Shaikh"
    },
    {
      "affiliations": [
        "Department of Radiology, Clinical Hospital Center 'Sisters of Mercy’, Zagreb, Croatia"
      ],
      "name": "Vedran Župančić"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, UTMB and Baylor School of Medicine, Houston, Texas, USA"
      ],
      "name": "Muhammad Ubaid Hafeez"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA"
      ],
      "name": "Joshua S Catapano"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, State University of New York at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Muhammad Waqas"
    },
    {
      "affiliations": [
        "Department of Radiology, Pamukkale University, Pamukkale, Turkey"
      ],
      "name": "Muhammet Arslan"
    },
    {
      "affiliations": [
        "Department of Radiology, Pamukkale University, Pamukkale, Turkey"
      ],
      "name": "Onur Ergun"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "James D Rabinov"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Austin Health, Melbourne, Victoria, Australia"
      ],
      "name": "Yifan Ren"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Radiology, Geisinger Hospital, Danville, Pennsylvania, USA"
      ],
      "name": "Clemens M Schirmer"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ospedale Niguarda Cà Granda, Milano, Italy"
      ],
      "name": "Mariangela Piano"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, UMass Memorial Hospital, Worcester, Massachusetts, USA"
      ],
      "name": "Anna Luisa Kuhn"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ospedale San Raffaele Sede di San Raffaele Turro, Milan, Italy"
      ],
      "name": "Caterina Michelozzi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Miami, Miami, Florida, USA"
      ],
      "name": "Robert M Starke"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Valley Baptist Neuroscience Institute, Harlingen, Texas, USA"
      ],
      "name": "Ameer E Hassan"
    },
    {
      "affiliations": [
        "Departments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Mark Ogilvie"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, University Hospital Basel, Basel, Switzerland"
      ],
      "name": "Anh Nguyen"
    },
    {
      "affiliations": [
        "Departments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Jesse Jones"
    },
    {
      "affiliations": [
        "Departments of Radiology and Neurosurgery, Mayo Clinic, Rochester, New York, USA"
      ],
      "name": "Waleed Brinjikji"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
      ],
      "name": "Marie Teresa Nawka"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, University Hospital Basel, Basel, Switzerland"
      ],
      "name": "Marios-Nikos Psychogios"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, UniversitätsKlinikum Heidelberg, Heidelberg, Germany"
      ],
      "name": "Christian Ulfert"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Bryan Pukenas"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Jan Karl Burkhardt"
    },
    {
      "affiliations": [
        "Departments of Radiology and Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA"
      ],
      "name": "Thien J Huynh"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, The University of Texas Health Science Center at Houston, Houston, Texas, USA"
      ],
      "name": "Juan Carlos Martinez-Gutierrez"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA",
        "Department of Neurosurgery, Montefiore Medical Center, Bronx, New York, USA"
      ],
      "name": "Muhammed Amir Essibayi"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University of Texas Health Science Center at Houston, Houston, Texas, USA"
      ],
      "name": "Sunil A Sheth"
    },
    {
      "affiliations": [
        "Department of Radiology, Stanford University School of Medicine, Stanford, California, USA"
      ],
      "name": "Diana Slawski"
    },
    {
      "affiliations": [
        "Neurosurgery, Mayo Clinic Hospital Jacksonville, Jacksonville, Florida, USA"
      ],
      "name": "Rabih Tawk"
    },
    {
      "affiliations": [
        "Radiology, Stanford University School of Medicine, Stanford, California, USA"
      ],
      "name": "Benjamin Pulli"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Hôpital Universitaire Erasme, Bruxelles, Belgium"
      ],
      "name": "Boris Lubicz"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ospedale San Raffaele, Milano, Italy"
      ],
      "name": "Pietro Panni"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, UMass Memorial Hospital, Worcester, Massachusetts, USA"
      ],
      "name": "Ajit S Puri"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Ospedale Niguarda Cà Granda, Milano, Italy"
      ],
      "name": "Guglielmo Pero"
    },
    {
      "affiliations": [
        "Departments of Radiology & Neurosurgery, NYU Langone Health Center, New York, New York, USA"
      ],
      "name": "Eytan Raz"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Christian Doppler University Hospital & Institute of Neurointervention, Salzburg, Austria"
      ],
      "name": "Christoph J Griessenauer"
    },
    {
      "affiliations": [
        "Departments of Radiology & Neurosurgery, NYU Langone Health Center, Dublin, Ireland"
      ],
      "name": "Hamed Asadi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, State University of New York at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Adnan H Siddiqui"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, State University of New York at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Elad I Levy"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Montefiore Medical Center, New York, New York, USA"
      ],
      "name": "Neil Haranhalli"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Montefiore Medical Center, New York, New York, USA"
      ],
      "name": "David Altschul"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA"
      ],
      "name": "Andrew F Ducruet"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA"
      ],
      "name": "Felipe C Albuquerque"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Robert W Regenhardt"
    },
    {
      "affiliations": [
        "Massachusetts General Hospital, Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Christopher J Stapleton"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, UTMB and Baylor School of Medicine, Galveston, Texas, USA"
      ],
      "name": "Peter Kan"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Clinical Hospital Center 'Sisters of Mercy’, Zagreb, Croatia"
      ],
      "name": "Vladimir Kalousek"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina"
      ],
      "name": "Pedro Lylyk"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Neuroradiology, New York Presbyterian Hospital and Weill Cornell School of Medicine, New York, New York, USA"
      ],
      "name": "Srikanth Reddy Boddu"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Neuroradiology, New York Presbyterian Hospital and Weill Cornell School of Medicine, New York, New York, USA"
      ],
      "name": "Jared Knopman"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Stavropoula I Tjoumakaris"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, Louisiana, USA"
      ],
      "name": "Hugo Cuellar"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Pascal Jabbour"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Hôpital Pitié-Salpêtrière, Paris, France"
      ],
      "name": "Frédéric Clarençon"
    },
    {
      "affiliations": [
        "Department of Neurosurgery and Neuroradiology, New York Presbyterian Hospital and Weill Cornell School of Medicine, New York, New York, USA"
      ],
      "name": "Nicola Limbucci"
    },
    {
      "affiliations": [
        "Neurovascular Centre, St Michael’s Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Vitor M Pereira"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Aman B Patel"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts, USA",
        "Neurovascular Centre, St Michael’s Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Adam A Dmytriw"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland"
      ],
      "name": "Steven D Hajdu"
    }
  ],
  "title": "Higher risk of recurrence in partially thrombosed cerebral aneurysms post-WEB (Woven EndoBridge) device treatment: insights from the WorldWideWEB Consortium registry",
  "uid": "2f31b70f-2330-5113-a07c-81d8c2c2c927"
}