{
  "abstract": "Introduction The ATLAS trial was a prospective, multicenter, single-arm, investigational device exemption (IDE) study to evaluate the safety and effectiveness of the Neuroform Atlas Stent System for the treatment of wide-necked bifurcation aneurysms. This analysis presents the 36-month follow-up data for the anterior and posterior cohorts.Methods Of the 182 patients in the IDE anterior cohort, 146 consented to participate in the post-approval study (PAS) and, of the 116 patients in the IDE posterior cohort, 101 consented to participate in the PAS. The primary effectiveness endpoint was core laboratory adjudicated (Raymond–Roy 1; RR1) without retreatment or parent artery stenosis (>50%) at 36 months post-procedure. The primary safety endpoint was Clinical Event Committee-adjudicated major ipsilateral stroke or neurological death through 36 months.Results There were 146 patients in the anterior cohort and 101 patients in the posterior cohort. At 24 months the composite effectiveness endpoint was 77.3% (34/44) in the anterior cohort and 65.5% (19/29) in the posterior cohort and at 36 months these rates were 92.3% (24/26) and 75.0% (18/24), respectively. RR1 rates at 24 months were 84.1% (37/44) in the anterior cohort and 70.0% (21/30) in the posterior cohort; at 36 months they were 96.3% (26/27) and 79.2% (19/24), respectively. By 36 months the primary safety endpoint occurred in 4.1% (6/146) of patients in the anterior cohort and 5.0% (5/101) in the posterior cohort.Conclusion The results of the long-term assessment of the Neuroform Atlas Stent System demonstrate favorable safety and effectiveness in the treatment of wide-necked bifurcation aneurysms without a single treated target aneurysm rupture beyond 12 months post-procedure.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurosurgery, JFK Health System, Edison, New Jersey, USA"
      ],
      "name": "Brian Jankowitz"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA"
      ],
      "name": "Ashutosh P Jadhav"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Bradley Gross"
    },
    {
      "affiliations": [
        "Department of Neurology, Cooper University Hospital, Camden, New Jersey, USA"
      ],
      "name": "Tudor G Jovin"
    },
    {
      "affiliations": [
        "Department of Diagnostic Radiology, Riverside Radiology and Interventional Associates Inc, Columbus, Ohio, USA"
      ],
      "name": "Abdulnasser A Alhajeri"
    },
    {
      "affiliations": [
        "Department of Neurological Surgery, University of Kentucky, Lexington, Kentucky, USA"
      ],
      "name": "Justin F Fraser"
    },
    {
      "affiliations": [
        "Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA"
      ],
      "name": "Ricardo A Hanel"
    },
    {
      "affiliations": [
        "Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA"
      ],
      "name": "Eric Sauvageau"
    },
    {
      "affiliations": [
        "Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA"
      ],
      "name": "Amin Aghaebrahim"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Radiology Imaging Associates, Englewood, Colorado, USA"
      ],
      "name": "Donald Frei"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Radiology Imaging Associates, Englewood, Colorado, USA"
      ],
      "name": "Richard Bellon"
    },
    {
      "affiliations": [
        "Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA"
      ],
      "name": "David N Loy"
    },
    {
      "affiliations": [
        "Department of Radiology, University of Massachusetts, Worcester, Massachusetts, USA"
      ],
      "name": "Ajit S Puri"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Tufts Medical Center, Boston, Massachusetts, USA"
      ],
      "name": "Adel M Malek"
    },
    {
      "affiliations": [
        "Department of Neurology, Cooper University Hospital, Camden, New Jersey, USA"
      ],
      "name": "Ajith J Thomas"
    },
    {
      "affiliations": [
        "Cerebrovascular Center, CCF, Cleveland Heights, Ohio, USA"
      ],
      "name": "Gabor Toth"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Advocate Health, Chicago, Illinois, USA"
      ],
      "name": "Demetrius Klee Lopes"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Rush University, Chicago, Illinois, USA"
      ],
      "name": "R Webster Crowley"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA"
      ],
      "name": "John Reavey-Cantwell"
    },
    {
      "affiliations": [
        "Neuroscience Department, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, Ohio, USA"
      ],
      "name": "Eugene Lin"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Adnan Siddiqui"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA"
      ],
      "name": "Michael J Alexander"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Wellstar Health System, Marietta, Georgia, USA"
      ],
      "name": "Ahmad Khaldi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA"
      ],
      "name": "Geoffrey P Colby"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Justin M Caplan"
    },
    {
      "affiliations": [
        "Department of Neurointerventional Surgery, CCHS, Newark, Delaware, USA"
      ],
      "name": "Sudhakar R Satti"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Prisma Health, Greenville, South Carolina, USA"
      ],
      "name": "Aquilla S Turk"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Alejandro M Spiotta"
    },
    {
      "affiliations": [
        "Division of Interventional Neuroradiology, Methodist Hospital System, Houston, Texas, USA"
      ],
      "name": "Richard Klucznik"
    },
    {
      "affiliations": [
        "Department of Radiology, University of Washington, Seattle, Washington, USA"
      ],
      "name": "Danial K Hallam"
    },
    {
      "affiliations": [
        "Division of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA"
      ],
      "name": "David Kung"
    },
    {
      "affiliations": [
        "Cerebrovascular Program, Vanderbilt University Medical Center, Nashville, Tennessee, USA"
      ],
      "name": "Michael T Froehler"
    },
    {
      "affiliations": [
        "Department of Interventional Neurology, Lawnwood Regional Medical Center and Heart Institute, Fort Pierce, Florida, USA"
      ],
      "name": "R Charles Callison"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA"
      ],
      "name": "Peter Kan"
    },
    {
      "affiliations": [
        "Department of Radiology, UCSF, San Francisco, California, USA"
      ],
      "name": "Steven W Hetts"
    },
    {
      "affiliations": [
        "Clinical Affairs, Stryker Neurovascular, Fremont, California, USA"
      ],
      "name": "Lori Lyn Price"
    },
    {
      "affiliations": [
        "Department of Neuroscience, St Vincent Mercy Hospital, Toledo, Ohio, USA"
      ],
      "name": "Osama O Zaidat"
    },
    {
      "affiliations": [],
      "name": "on behalf of the ATLAS Investigators"
    }
  ],
  "title": "Post-approval study 3-year outcomes of the Neuroform Atlas stent for the treatment of wide-necked intracranial aneurysms",
  "uid": "09747b51-29f6-5657-9caa-fbf64f173f46"
}