{
  "abstract": "Background Intrasaccular devices have broadened treatment options for wide necked aneurysms. This study presents the preliminary experience with the Artisse 2.0 device.Methods Innovative NeurovaScular Product SurveIllance REgistry (INSPIRE) is a non-randomized, multicenter, real world clinical study with treatment arms for aneurysms (INSPIRE-A) and acute ischemic stroke (INSPIRE-S). This interim analysis included 87 patients enrolled from November 2022 to April 2024 in the INSPIRE-A Artisse cohort across 16 Europoean centers. Procedures followed standard clinical care, with 6 months of follow-up. Safety and efficacy endpoints included major stroke, neurological death, serious adverse events (SAEs), aneurysm occlusion, and retreatment rates. An independent core laboratory assessed imaging, and all SAEs were reviewed by a clinical events committee. The Artisse steering committee provided independent oversight of the data.Results The Artisse device achieved an overall successful implantation rate of 96.6% (84/87), with satisfactory placement rates of 98.7% (74/75) for unruptured and 88.9% (8/9) for ruptured aneurysms. Following the procedure, 46.2% of unruptured aneurysm patients were receiving antiplatelet therapy (APT), predominantly aspirin monotherapy, while no ruptured aneurysm patients received APT. Device related SAE rate was 1.3% (1/87), and the overall stroke rate was 2.3% (2/87), including both ruptured and unruptured aneurysms. At 6 months, 80.0% (28/35) of patients with unruptured aneurysms showed complete obliteration, with no recurrences or retreatments.Conclusions Preliminary experience with the Artisse 2.0 device demonstrated high technical success, favorable safety, and efficacy in aneurysm obliteration at 6 months. Larger studies with longer follow-up periods are needed to confirm these findings.",
  "authors": [
    {
      "affiliations": [
        "Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany"
      ],
      "name": "Sophia Hohenstatt"
    },
    {
      "affiliations": [
        "Neuroradiology, Hôpital Gui de Chauliac, Montpellier, France"
      ],
      "name": "Vincent Costalat"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital Centre Montpellier, Montpellier, France"
      ],
      "name": "Cyril Dargazanli"
    },
    {
      "affiliations": [
        "Neurology/Research Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria"
      ],
      "name": "Monika Killer-Oberpfalzer"
    },
    {
      "affiliations": [
        "Department of Anaesthesiology and Intensive Care, Paracelsus Medical University, Salzburg, Austria"
      ],
      "name": "Barbara Schreiber"
    },
    {
      "affiliations": [
        "Department of Interventional Radiology, Turku University Hospital Polyclinic of Physical Medicine, Turku, Finland"
      ],
      "name": "Riitta Rautio"
    },
    {
      "affiliations": [
        "Department of Interventional Radiology, Turku University Hospital Polyclinic of Physical Medicine, Turku, Finland"
      ],
      "name": "Matias Sinisalo"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology. Radiology, Queen Elizabeth Hospital, Birmingham, UK"
      ],
      "name": "Saleh Lamin"
    },
    {
      "affiliations": [
        "Neuroradiology, Queen Elizabeth Hospital Birmingham, Birmingham, UK"
      ],
      "name": "Han Seng Chew"
    },
    {
      "affiliations": [
        "NEURI The Brain Vascular Centre, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France",
        "Paris-Saclay University Faculty of Medicine, Le Kremlin-Bicetre, France"
      ],
      "name": "Laurent Spelle"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology Section, Department of Radiology, Vall d'Hebron University Hospital, Barcelona, Spain",
        "Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Barcelona, Spain"
      ],
      "name": "Alejandro Tomasello"
    },
    {
      "affiliations": [
        "Leeds General Infirmary, Leeds, UK"
      ],
      "name": "Tufail Patankar"
    },
    {
      "affiliations": [
        "Neuroradiology, Ospedale Niguarda Ca Granda, Milano, Italy"
      ],
      "name": "Mariangela Piano"
    },
    {
      "affiliations": [
        "University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
      ],
      "name": "Jens Fiehler"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany"
      ],
      "name": "Markus A Möhlenbruch"
    }
  ],
  "title": "New Artisse intrasaccular device for intracranial aneurysm treatment: short term clinical and angiographic result from the prospective registry INSPIRE-A",
  "uid": "e5550a33-3985-5b07-8742-70597b611f0f"
}