{
  "abstract": "Background Although recently presented randomized trials have failed to prove an overall benefit of mechanical thrombectomy (MT) for patients with medium vessel occlusions (MeVOs), questions remain unanswered, particularly regarding the technology and the role of dedicated small devices. This prospective multicenter, core lab reviewed registry study investigates the efficacy and safety of the APERIO Hybrid used as a first-line device for the treatment of MeVO patients.Methods Data from all MeVO patients who underwent MT with the APERIO or APERIO Hybrid 17 as a first-line technique were prospectively included. The primary endpoint was the successful recanalization (Thrombolysis In Cerebral Infarction (TICI) 2b/3) after up to three passes with the APERIO without the use of a rescue technique and without any symptomatic intracranial hemorrhage (ICH).Results 134 patients were enrolled from 10 stroke centers. The primary endpoint was reached in 97 patients (81.5%, 95% CI 74.5% to 88.5%). In patients who failed the primary endpoint, TICI 2b/3 was reached with 4 to 6 APERIO passes in 4 patients (3.3%) and with other techniques in 18 patients (15%). Overall recanalization success was 95.8%. TICI 2b/3 with APERIO Hybrid was achieved after the first pass in 76 patients (63.9%), in 23 (19.3%) after 2 passes, and in 1 patient (0.8%) after 3 passes. Modified Rankin Scale (mRS) 0–2 at 90 days was reached by 79.0% of the patients. Symptomatic ICH occurred in no patients, asymptomatic ICH in 16 (13.5%), and subarachnoid hemorrhage in 15 patients (12.6%).Conclusion APERIO and APERIO Hybrid 17 have been proven to be both safe and effective first-line devices for MT in MeVO stroke at different centers and with high rates of successful recanalization.",
  "authors": [
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital Bonn, Bonn, Germany",
        "Neuroradiology, University Hospital Munich Campus Grosshadern Scientific Library, Munich, Germany"
      ],
      "name": "Franziska Dorn"
    },
    {
      "affiliations": [
        "University Department for Radiology, Neuroradiology and Nuclear Medicine, Muhlenkreiskliniken, Minden, Germany"
      ],
      "name": "Jan Borggrefe"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology, Klinikum Fulda gAG, Fulda, Germany"
      ],
      "name": "Kai Kallenberg"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Gottingen, Germany"
      ],
      "name": "Marielle Ernst"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, University Hospital Magdeburg, Magdeburg, Germany"
      ],
      "name": "Daniel Behme"
    },
    {
      "affiliations": [
        "Schlosspark-Klinik GmbH, Berlin, Germany"
      ],
      "name": "Annette Foerschler"
    },
    {
      "affiliations": [
        "Neuroradiology, University Hospital Cologne, Cologne, Germany"
      ],
      "name": "Christoph Kabbasch"
    },
    {
      "affiliations": [
        "Dept. of Neuroradiology, Ludwig Maximilian University of Munich, Munchen, Germany"
      ],
      "name": "Thomas Liebig"
    },
    {
      "affiliations": [
        "Radiology, University Hospital of Düsseldorf, Düsseldorf, Germany"
      ],
      "name": "Bernd Turowski"
    },
    {
      "affiliations": [
        "Department of Neuroradiology, Städtisches Klinikum Solingen, Solingen, Germany",
        "Department of Health, Witten/Herdecke University, Witten, Germany"
      ],
      "name": "Hannes Nordmeyer"
    }
  ],
  "title": "REcanalization of Distal Cerebral Vessels In Acute Stroke Using ApeRio (REVISAR)",
  "uid": "564b5c2a-963d-5187-9a10-19e33a5cf943"
}