{
  "abstract": "Brain aneurysms occupy a unique and somewhat paradoxical position in cerebrovascular disease. Although unruptured aneurysms are relatively common, affecting approximately 2–5% of the adult population, their most catastrophic consequence, aneurysmal subarachnoid hemorrhage (aSAH), remains comparatively rare, with an estimated global incidence of 7.9 (95% CI 6.9 to 9.0) per 100 000 person-years.1 This imbalance yields a condition that carries profound neurological morbidity and mortality, disproportionately affecting individuals in midlife, yet occurs with too low a frequency to command the research attention, infrastructure, and funding typically devoted to high-burden disorders such as ischemic stroke. As a result, brain aneurysms function in many respects—scientifically, structurally, and economically—like an orphan disease.",
  "authors": [
    {
      "affiliations": [
        "Interventional Neuroradiology/Endovascular Neurosurgery Division, Department of Neurology, Neurosurgery and Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Edgar A Samaniego"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University at Buffalo, Buffalo, New York, USA",
        "Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Vincent M Tutino"
    }
  ],
  "title": "When common lesions behave like a rare disease: The case for orphan status in brain aneurysm research",
  "uid": "38e69825-b074-5b40-9327-a348374edacb"
}