{
  "abstract": "Background The Contour Neurovascular System (CNS, Stryker, Kalamazoo, MI) has a unique design that allows it to address various aneurysm morphologies, including wide-necked, irregular, and shallow-shaped lesions. However, evidence of its safety and efficacy remains limited. This systematic review and meta-analysis synthesizes the current data on CNS performance.Methods A comprehensive search guided by the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) standards was performed across PubMed, Embase, and Web of Science, including studies with ≥5 patients reporting on CNS use. Efficacy outcomes included immediate and last follow-up adequate aneurysm occlusion and technical success. Safety outcomes included good functional outcome (modified Rankin Scale (mRS) score of 0–2 at last follow-up), procedure-related morbidity (permanent neurological deficits), procedure-related mortality, intraoperative and postoperative complications. Pooled analyses with 95% confidence intervals (CI) were conducted, with heterogeneity assessed using I² statistics, and a random-effects model was applied.Results Nine studies, including 483 patients (58.8% female; mean age: 59.3±15.6 years) with 484 aneurysms, were analyzed. Of the 467 patients in whom rupture status was reported, 81.8% presented with unruptured aneurysms and 18.2% with ruptured aneurysms. Immediate adequate aneurysm occlusion rate was 53% (95% CI: 1% to 100%), with follow-up adequate occlusion at 93% (95% CI: 88% to 97%) and technical success at 98% (95% CI: 95% to 100%). Intraoperative and postoperative complication rates were 3% (95% CI: 0% to 7%) and 7% (95% CI: 3% to 12%), respectively. Procedure-related morbidity was 2% (95% CI: 0% to 3%), with no procedure-related mortality.Conclusion The CNS is a safe and effective novel intrasaccular device for treating intracranial aneurysms.",
  "authors": [
    {
      "affiliations": [
        "Department of Radiology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey"
      ],
      "name": "Ahmet Günkan"
    },
    {
      "affiliations": [
        "Diagnostic and Interventional Neuroradiology, Hospital Foch, Créteil, France"
      ],
      "name": "Luca Scarcia"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Lenox Hill Hospital, New York, New York, USA"
      ],
      "name": "Marcio Yuri Ferreira"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Catholic University of Brasilia, Brasilia, DF, Brazil"
      ],
      "name": "Marina Vilardo"
    },
    {
      "affiliations": [
        "School of Medicine, Pontifical Catholic University of Paraná, Parana, Brazil"
      ],
      "name": "Luis Flavio Fabrini Paleare"
    },
    {
      "affiliations": [
        "Academic Department of Surgery, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru"
      ],
      "name": "Jhon E Bocanegra-Becerra"
    },
    {
      "affiliations": [
        "Département de Radiologie et Imagerie Médicale, Centre Hospitalier Universitaire Dijon (Hospital Center University François Mitterrand), Dijon, France"
      ],
      "name": "Mohamed E M Fouad"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Universidade Estácio de Sá, Rio De Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Henrique Garcia Maia"
    },
    {
      "affiliations": [
        "University of West Santa Catarina, Joaçaba, Santa Catarina, Brazil"
      ],
      "name": "Gabriel Semione"
    },
    {
      "affiliations": [
        "UOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"
      ],
      "name": "Andrea Maria Alexandre"
    },
    {
      "affiliations": [
        "Civil engineering, University College London, London, UK"
      ],
      "name": "Leonardo Vilardo"
    },
    {
      "affiliations": [
        "Sorbonne Université, Paris, France",
        "Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France"
      ],
      "name": "Frédéric Clarençon"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Lenox Hill Hospital, New York, New York, USA"
      ],
      "name": "Yafell Serulle"
    },
    {
      "affiliations": [
        "Neurological surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Pascal Jabbour"
    }
  ],
  "title": "Safety and efficacy of the Contour Neurovascular System for treating intracranial aneurysms: a systematic review and meta-analysis",
  "uid": "36e05a91-0533-58de-aa27-a37284162e7b"
}