{
  "abstract": "Background The Flow Re-direction Endoluminal Device (FRED) X is a next generation flow-diverting stent for treating intracranial aneurysms. Its surface modification (X technology) aims to minimize device thrombogenicity. Early post-market multicenter data from the US are lacking.Methods We conducted a retrospective multicenter analysis of consecutive FRED X procedures performed to treat unruptured intracranial aneurysms at four US centers (March 2022 to January 2024). Cases with ruptured aneurysms or extracranial aneurysm location were excluded (n=10). We assessed patient and aneurysm characteristics, antithrombotic management, safety events, and both clinical and angiographic (effectiveness) outcomes.Results In this cohort, 101 patients underwent FRED X stenting for 117 aneurysms. Most aneurysms were saccular in shape (95.7%) and located at the C6–C7 segments of the internal carotid artery (72.6%). Thromboembolic events occurred in 5.9% of the cases, leading to one instance of permanent procedure related morbidity (1.0%). No procedure related mortality (0%) was observed. Device related issues were recorded in 2.0% of cases. At the 6 month follow-up, complete aneurysm occlusion was achieved in 58% of aneurysms. At the last available follow-up (6–12 months), 74.8% of aneurysms were adequately occluded.Conclusions FRED X stenting for unruptured intracranial aneurysms demonstrated low rates of neurological morbidity and periprocedural complications. Early aneurysm occlusion rates were appropriate, but further mid-term and long term follow-up is required. These findings support the early safety and effectiveness of the FRED X device for intracranial aneurysm treatment.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger, Danville, Pennsylvania, USA"
      ],
      "name": "Philipp Hendrix"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger, Danville, Pennsylvania, USA"
      ],
      "name": "Sina Hemmer"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Georgios S Sioutas"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Albany Medical Center, Albany, New York, USA"
      ],
      "name": "Nicholas C Field"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Montefiore Health System, Bronx, New York, USA"
      ],
      "name": "Muhammed Amir Essibayi"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Mohamed M Salem"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Visish M Srinivasan"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Albany Medical Center, Albany, New York, USA"
      ],
      "name": "Amanda Custozzo"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Montefiore Health System, Bronx, New York, USA"
      ],
      "name": "Alireza Karandish"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Montefiore Health System, Bronx, New York, USA"
      ],
      "name": "David Altschul"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Albany Medical Center, Albany, New York, USA"
      ],
      "name": "Alexandra R Paul"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Jan-Karl Burkhardt"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger, Danville, Pennsylvania, USA"
      ],
      "name": "Clemens M Schirmer"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Geisinger, Danville, Pennsylvania, USA"
      ],
      "name": "Oded Goren"
    }
  ],
  "title": "FRED X flow diversion stenting for unruptured intracranial aneurysms: US multicenter post-market study",
  "uid": "f6358562-9aff-5397-ac98-9e495aa06d61"
}