{
  "abstract": "The cerebral blood volume index (CBV index) is a perfusion-based marker of collateral status. Several real-world data analyses from observational stroke cohorts have established relationships between this parameter and a range of favorable and unfavorable stroke outcomes. In this review, an overview is provided of the CBV index, within the context of thrombectomy-treated large vessel and medium vessel occlusion ischemic strokes. The current literature is summarized describing the CBV index and its association with a variety of efficacy, safety, and clinical outcome measures during the thrombectomy course and post-treatment recovery in both large vessel occlusion and medium vessel occlusion strokes. The range of CBV index value thresholds that have been identified and are able to differentiate between favorable and unfavorable outcomes across different clinical scenarios are summarized. This review underscores the need for additional analyses to further explore the CBV index in other clinical outcome contexts and for future prospective studies to validate the CBV index in thrombectomy-treated large vessel and medium vessel occlusion strokes, especially with increasing use of thrombectomy for treating medium vessel occlusions.",
  "authors": [
    {
      "affiliations": [
        "Cooper University Health Care, Camden, New Jersey, USA"
      ],
      "name": "Manisha Koneru"
    },
    {
      "affiliations": [
        "West Virginia University, Morgantown, West Virginia, USA"
      ],
      "name": "Dhairya A Lakhani"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Risheng Xu"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Hamza Adel Salim"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Victor C Urrutia"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Elisabeth B Marsh"
    },
    {
      "affiliations": [
        "Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Adam A Dmytriw"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, Universite Libre De Bruxelles, Brussels, Belgium"
      ],
      "name": "Adrien Guenego"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Rafael H Llinas"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Argye E Hillis"
    },
    {
      "affiliations": [
        "University of California San Francisco, San Francisco, California, USA"
      ],
      "name": "Kambiz Nael"
    },
    {
      "affiliations": [
        "MD Anderson Children’s Cancer Hospital, Houston, Texas, USA"
      ],
      "name": "Max Wintermark"
    },
    {
      "affiliations": [
        "Stanford University School of Medicine, Stanford, California, USA"
      ],
      "name": "Gregory W Albers"
    },
    {
      "affiliations": [
        "Stanford University School of Medicine, Stanford, California, USA"
      ],
      "name": "Jeremy J Heit"
    },
    {
      "affiliations": [
        "University Medical Center Munster, Munster, Germany"
      ],
      "name": "Tobias D Faizy"
    },
    {
      "affiliations": [
        "Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Vivek Yedavalli"
    }
  ],
  "title": "Cerebral blood volume index in the era of thrombectomy-treated large and medium vessel ischemic strokes",
  "uid": "b8a565a4-dcf4-5c2d-8be1-bd76fffe2308"
}