{
  "abstract": "Background This study aimed to perform a comprehensive pooled analysis of all published series involving pediatric patients with large vessel occlusion (LVO) undergoing endovascular treatment (EVT) to study the disease landscape including presentation, management, and outcomes.Methods The data used in this study were pooled from published literature on EVT for pediatric stroke spanning from 1980 to 2023. The relevant articles were carefully reviewed, and only those reporting at least one case of pediatric LVO undergoing EVT were included. Furthermore, pediatric patients with LVO who received EVT from the Chinese Pediatric Ischemic Stroke Registry database were also included. The primary outcome for this study was the unfavorable outcome after stroke. The risk factors influencing the outcomes of patients with pediatric stroke treated with EVT were analyzed using Cox proportional hazards models.Results A total of 221 pediatric patients who underwent EVT were included. During an average follow-up period of 6 months, 20.8% of patients had an unfavorable outcome. Multivariate Cox regression showed that patients with a higher Pediatric National Institutes of Health Stroke Scale (pedNIHSS) score (aHR=7.54, 95% CI 2.38 to 23.58) and unsuccessful reperfusion (aHR=5.84, 95% CI 2.86 to 11.93) were associated with an increased risk of unfavorable outcomes, while older age (aHR=0.27, 95% CI 0.09 to 0.82) was associated with a lower risk of unfavorable outcomes.Conclusion Following EVT treatment, a significant proportion of pediatric patients with LVO achieved favorable outcomes. However, factors such as the severity of the pedNIHSS score and unsuccessful reperfusion were found to be associated with a poorer prognosis.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Hefei, Anhui, China"
      ],
      "name": "Wanqiu Zhang"
    },
    {
      "affiliations": [
        "Department of Nephrology and Rheumatology, Hunan Children' s Hospital, Changsha, Hunan, China"
      ],
      "name": "Cuirong Duan"
    },
    {
      "affiliations": [
        "Department of Critical Care Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China"
      ],
      "name": "Mingyang Niu"
    },
    {
      "affiliations": [
        "Department of Pediatrics, The 7th Medical Center of Chinese PLA General Hospital, Beijing, Beijing, China"
      ],
      "name": "Bin Zhu"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Hefei, Anhui, China"
      ],
      "name": "Jinghui Zhong"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Hefei, Anhui, China"
      ],
      "name": "Yingjie Xu"
    },
    {
      "affiliations": [
        "Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China"
      ],
      "name": "Lulu Xiao"
    },
    {
      "affiliations": [
        "Department of Emergency, Panyu Maternal And Child Care Service Centre Of Guangzhou, Guangzhou, Guangdong, China"
      ],
      "name": "Qiankun Li"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Hefei, Anhui, China"
      ],
      "name": "Xinfeng Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Hefei, Anhui, China"
      ],
      "name": "Wen Sun"
    }
  ],
  "title": "Endovascular treatment in pediatric stroke: an individual patient pooled analysis on presentation, management and outcomes",
  "uid": "1ec277cd-fb8b-5aa2-ac13-d73f41fd7040"
}