{
  "abstract": "Background The aim of this study was to investigate the relationships between imaging indicators of obesity, as measured by computed tomography (CT), and clinical outcomes at 90 days and 1 year after emergent endovascular therapy (EVT).Methods Participants with emergent large vessel occlusion (ELVO) who underwent EVT were prospectively enrolled. During hospitalization, CT scans were performed to evaluate the visceral adipose tissue area (VATA) and skeletal muscle area (SMA) at the level of the third lumbar spine. Multivariate regression analysis was used to assess the correlation of obesity-related imaging measures with various outcomes: mortality, favorable functional outcomes (modified Rankin scale (mRS) score 0–2), and functional improvement (shift in mRS score) at 90 days and 1 year.Results A total of 306 ELVO patients were included in the study, with a median age of 64 years and a median baseline National Institutes of Health Stroke Scale (NIHSS) score of 18. After adjusting for potential confounders, the VATA-to-SMA ratio (VSR) was significantly associated with a favorable functional outcome (OR 0.30, 95% CI 0.13 to 0.70) at 90 days and a favorable functional outcome (OR 0.27, 95% CI 0.12 to 0.61) and functional improvement (OR 0.33, 95% CI 0.12 to 0.92) at the 1 year follow-up.Conclusion Our study indicated that lower VSR levels are associated with favorable functional outcomes, along with functional improvement at 90 days and 1 year of follow-up.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"
      ],
      "name": "Chengcheng Cui"
    },
    {
      "affiliations": [
        "Department of Neurology, Huaian Hospital of Huaian City, Huaian Cancer Hospital, Huaian, Jiangsu, China, Huaian, China"
      ],
      "name": "Zhiwen Geng"
    },
    {
      "affiliations": [
        "Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China, Xuzhou, China"
      ],
      "name": "Hao Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, Cixi People's Hospital, Cixi, Zhejiang, China, Cixi, China"
      ],
      "name": "Mengxia Lu"
    },
    {
      "affiliations": [
        "Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China, Xuzhou, China"
      ],
      "name": "Yuqiao Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China, Xuzhou, China"
      ],
      "name": "Dayong Shen"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China"
      ],
      "name": "Rui Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"
      ],
      "name": "Lulu Xiao"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"
      ],
      "name": "Xinfeng Liu"
    }
  ],
  "title": "Effect of abnormal distribution of abdominal adiposity and skeletal muscle on the outcomes of endovascular treatment for emergent large vessel occlusion",
  "uid": "07986d9b-3f76-5056-8fba-cbf0af150279"
}