{
  "abstract": "Background Flow diverters (FDs) revolutionized cerebral aneurysm treatment by promoting aneurysm sac sealing but have limitations, including thromboembolic complications and incomplete occlusion. Rosuvastatin enhances endothelialization via endothelial progenitor cell mobilization and nitric oxide bioavailability, potentially improving FD healing. This study assessed the effect of rosuvastatin on FD endothelialization in a rabbit aneurysm model.Methods Twenty-two rabbits with elastase-induced aneurysms underwent FD implantation in the right subclavian artery. In the same animals, FDs were placed in the descending aorta to assess side branch patency. Thirteen rabbits received rosuvastatin plus aspirin (Rosu+ASA; 10 mg/kg/day each) and nine received aspirin alone (ASA; 10 mg/kg/day). Two weeks post-implantation, aneurysm occlusion (O’Kelly-Marotta scale), side branch patency (high frequency optical coherence tomography), and histological/MPM strut coverage were evaluated. Rosuvastatin serum concentration was correlated with endothelial cell coverage.Results Complete aneurysm occlusion (OKM D) occurred in 11/13 (84.6%) of Rosu+ASA vs 6/9 (66.6%) of ASA animals. Patency of branches ≥1 mm was higher with Rosu+ASA (17/18 (94.4%) vs 9/13 (46.1%), PP=0.007), as was patency of branches <1 mm (21/22 (95.4%) vs 11/15 (73.4%), P=0.036). The composite outcome (complete occlusion+patent branches) favored Rosu+ASA (10/13 (76.9%) vs 2/9 (22.2%), P=0.011). Histology showed a trend toward greater strut coverage and neointimal thickness in Rosu+ASA (P=0.1). Rosuvastatin serum concentration strongly correlated with endothelial cell coverage (r=0.92, P=0.02).Conclusion In rabbit FD models, rosuvastatin therapy seems to improve aneurysm occlusion, preserving side branch patency. We also found an association between drug levels and endothelial cells covering the FD. These findings support further investigations.",
  "authors": [
    {
      "affiliations": [
        "Interventional Neuroradiology, Vall d’Hebron University Hospital, Barcelona, Spain",
        "Department of Life, Health and Health Professions Sciences, Link Campus University, Rome, Italy",
        "Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Section of Neurosciences, Salerno, Italy"
      ],
      "name": "Francesco Diana"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Géraud Forestier"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France",
        "Vascular surgery, CHU Dupuytren 2, Limoges, France"
      ],
      "name": "Romain Chauvet"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Marie Laure Perrin"
    },
    {
      "affiliations": [
        "Radiology, CHU Limoges, Limoges, France"
      ],
      "name": "Maxime Baudouin"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France",
        "Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, Île-de-France, France"
      ],
      "name": "Jonathan Cortese"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Alexis Belgacem"
    },
    {
      "affiliations": [
        "Institute of Epidemiology and Global Health - Michel Dumas, OmegaHealth; Inserm, U1094; IRD, UMR270; EpiMaCT (Epidemiology of chronic diseases in tropical zone), CHU Limoges, Department of Pharmacy, University of Limoges, Limoges, France"
      ],
      "name": "Voahirana Ratsimnazafy"
    },
    {
      "affiliations": [
        "Service de Pharmacie, CHU Limoges, Limoges, France"
      ],
      "name": "Marine Coulomb"
    },
    {
      "affiliations": [
        "Service de Pharmacie, CHU Limoges, Limoges, France"
      ],
      "name": "Margot D’Arrigo"
    },
    {
      "affiliations": [
        "Service de Pharmacie, CHU Limoges, Limoges, France"
      ],
      "name": "Edouard Lefebvre"
    },
    {
      "affiliations": [
        "Service de Pharmacie, CHU Limoges, Limoges, France"
      ],
      "name": "Sylvain Dulaurent"
    },
    {
      "affiliations": [
        "Service de Pharmacie, CHU Limoges, Limoges, France"
      ],
      "name": "Nicolas Picard"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Heloise Daverat"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Gregory Sasselina"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Daphnee Chandellier"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Jérémy Mounier"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Claude Couquet"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Caroline Croguennec"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Ludovic Micallef"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Aurelien Le Flahec"
    },
    {
      "affiliations": [
        "Plateform EMIS, CHU Limoges, Limoges, France"
      ],
      "name": "Nicolas Dubois"
    },
    {
      "affiliations": [
        "Neurology and Stroke Unit, Maurizio Bufalini Hospital, Cesena, Emilia-Romagna, Italy"
      ],
      "name": "Michele Romoli"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology, CHU Limoges, Limoges, France"
      ],
      "name": "Charbel Mounayer"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Sylvia M Bardet"
    },
    {
      "affiliations": [
        "Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Section of Neurosciences, Salerno, Italy"
      ],
      "name": "Francesco Di Salle"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"
      ],
      "name": "Faraj Terro"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University Limoges, Limoges, France",
        "Interventional Neuroradiology, CHU Limoges, Limoges, France"
      ],
      "name": "Aymeric Rouchaud"
    }
  ],
  "title": "Rosuvastatin for intracranial aneurysms treated with flow diverters: preclinical study in rabbits",
  "uid": "40e3f72f-f81c-5578-be0d-f4fd2e44d84e"
}